Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1990302..1990911 | Replicon | chromosome |
Accession | NZ_AP018795 | ||
Organism | Acidithiobacillus ferridurans strain JCM 18981 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | AFERRID_RS10280 | Protein ID | WP_113526787.1 |
Coordinates | 1990636..1990911 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | graA | Uniprot ID | - |
Locus tag | AFERRID_RS10275 | Protein ID | WP_126605156.1 |
Coordinates | 1990302..1990619 (-) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AFERRID_RS10260 | 1986148..1986357 | - | 210 | Protein_1989 | chloride channel protein | - |
AFERRID_RS10265 | 1986448..1987341 | + | 894 | WP_126605154.1 | LysR family transcriptional regulator | - |
AFERRID_RS10270 | 1987498..1989927 | - | 2430 | WP_126605155.1 | plasma-membrane proton-efflux P-type ATPase | - |
AFERRID_RS10275 | 1990302..1990619 | - | 318 | WP_126605156.1 | HigA family addiction module antidote protein | Antitoxin |
AFERRID_RS10280 | 1990636..1990911 | - | 276 | WP_113526787.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
AFERRID_RS10285 | 1991301..1991585 | + | 285 | WP_126605157.1 | hypothetical protein | - |
AFERRID_RS10290 | 1991575..1993598 | - | 2024 | Protein_1995 | copper-translocating P-type ATPase | - |
AFERRID_RS10295 | 1993737..1994000 | - | 264 | WP_126605158.1 | SHOCT domain-containing protein | - |
AFERRID_RS10300 | 1994284..1995036 | - | 753 | WP_126605159.1 | MBL fold metallo-hydrolase | - |
AFERRID_RS10305 | 1995090..1995431 | - | 342 | WP_113526783.1 | DsrE family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10443.87 Da Isoelectric Point: 7.8785
>T32278 WP_113526787.1 NZ_AP018795:c1990911-1990636 [Acidithiobacillus ferridurans]
MIRSFVHKGLKQVFETGQSAKVGADLVTRCKRRLDAINAAVSPEELNVPGFDFHALEGKPKRYTVYVNGPYCITFEWREG
DAWRVDLENYH
MIRSFVHKGLKQVFETGQSAKVGADLVTRCKRRLDAINAAVSPEELNVPGFDFHALEGKPKRYTVYVNGPYCITFEWREG
DAWRVDLENYH
Download Length: 276 bp
>T32278 NZ_AP018795:c1990911-1990636 [Acidithiobacillus ferridurans]
TTGATACGAAGTTTTGTGCATAAGGGCCTCAAGCAGGTTTTCGAGACGGGTCAATCGGCGAAAGTCGGTGCGGATTTGGT
GACCCGCTGCAAGCGCAGACTCGATGCCATAAACGCTGCAGTATCCCCGGAGGAGTTGAACGTGCCAGGTTTCGACTTCC
ATGCTTTGGAGGGGAAACCGAAGCGGTACACGGTTTATGTGAATGGACCCTATTGCATCACCTTCGAGTGGCGTGAAGGA
GATGCCTGGCGCGTTGATCTGGAGAATTACCATTAA
TTGATACGAAGTTTTGTGCATAAGGGCCTCAAGCAGGTTTTCGAGACGGGTCAATCGGCGAAAGTCGGTGCGGATTTGGT
GACCCGCTGCAAGCGCAGACTCGATGCCATAAACGCTGCAGTATCCCCGGAGGAGTTGAACGTGCCAGGTTTCGACTTCC
ATGCTTTGGAGGGGAAACCGAAGCGGTACACGGTTTATGTGAATGGACCCTATTGCATCACCTTCGAGTGGCGTGAAGGA
GATGCCTGGCGCGTTGATCTGGAGAATTACCATTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11758.52 Da Isoelectric Point: 5.6631
>AT32278 WP_126605156.1 NZ_AP018795:c1990619-1990302 [Acidithiobacillus ferridurans]
MDEMTVEQVDRTPTHPGEILREEVLPALDISVAEFARGLRVSRQTVHGILSERKGITPEMALRIGKYLGNGPGIWLRMQQ
AYDLTIAERRLAEELAAIHKPEQAA
MDEMTVEQVDRTPTHPGEILREEVLPALDISVAEFARGLRVSRQTVHGILSERKGITPEMALRIGKYLGNGPGIWLRMQQ
AYDLTIAERRLAEELAAIHKPEQAA
Download Length: 318 bp
>AT32278 NZ_AP018795:c1990619-1990302 [Acidithiobacillus ferridurans]
ATGGACGAAATGACCGTTGAGCAGGTGGACCGGACACCGACGCATCCGGGCGAGATATTGCGGGAGGAGGTACTGCCTGC
ACTGGATATCTCTGTAGCAGAGTTTGCCCGTGGCCTGCGGGTCTCGCGCCAGACCGTTCACGGCATCCTGTCCGAGCGCA
AAGGCATTACCCCAGAGATGGCCTTGCGTATCGGCAAGTATCTGGGTAACGGGCCGGGGATATGGCTACGCATGCAACAG
GCTTACGATTTGACCATTGCGGAACGTCGGTTGGCCGAAGAACTGGCGGCCATTCACAAGCCCGAGCAAGCCGCCTGA
ATGGACGAAATGACCGTTGAGCAGGTGGACCGGACACCGACGCATCCGGGCGAGATATTGCGGGAGGAGGTACTGCCTGC
ACTGGATATCTCTGTAGCAGAGTTTGCCCGTGGCCTGCGGGTCTCGCGCCAGACCGTTCACGGCATCCTGTCCGAGCGCA
AAGGCATTACCCCAGAGATGGCCTTGCGTATCGGCAAGTATCTGGGTAACGGGCCGGGGATATGGCTACGCATGCAACAG
GCTTACGATTTGACCATTGCGGAACGTCGGTTGGCCGAAGAACTGGCGGCCATTCACAAGCCCGAGCAAGCCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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