Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1990302..1990911 Replicon chromosome
Accession NZ_AP018795
Organism Acidithiobacillus ferridurans strain JCM 18981

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AFERRID_RS10280 Protein ID WP_113526787.1
Coordinates 1990636..1990911 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag AFERRID_RS10275 Protein ID WP_126605156.1
Coordinates 1990302..1990619 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFERRID_RS10260 1986148..1986357 - 210 Protein_1989 chloride channel protein -
AFERRID_RS10265 1986448..1987341 + 894 WP_126605154.1 LysR family transcriptional regulator -
AFERRID_RS10270 1987498..1989927 - 2430 WP_126605155.1 plasma-membrane proton-efflux P-type ATPase -
AFERRID_RS10275 1990302..1990619 - 318 WP_126605156.1 HigA family addiction module antidote protein Antitoxin
AFERRID_RS10280 1990636..1990911 - 276 WP_113526787.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFERRID_RS10285 1991301..1991585 + 285 WP_126605157.1 hypothetical protein -
AFERRID_RS10290 1991575..1993598 - 2024 Protein_1995 copper-translocating P-type ATPase -
AFERRID_RS10295 1993737..1994000 - 264 WP_126605158.1 SHOCT domain-containing protein -
AFERRID_RS10300 1994284..1995036 - 753 WP_126605159.1 MBL fold metallo-hydrolase -
AFERRID_RS10305 1995090..1995431 - 342 WP_113526783.1 DsrE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10443.87 Da        Isoelectric Point: 7.8785

>T32278 WP_113526787.1 NZ_AP018795:c1990911-1990636 [Acidithiobacillus ferridurans]
MIRSFVHKGLKQVFETGQSAKVGADLVTRCKRRLDAINAAVSPEELNVPGFDFHALEGKPKRYTVYVNGPYCITFEWREG
DAWRVDLENYH

Download         Length: 276 bp

>T32278 NZ_AP018795:c1990911-1990636 [Acidithiobacillus ferridurans]
TTGATACGAAGTTTTGTGCATAAGGGCCTCAAGCAGGTTTTCGAGACGGGTCAATCGGCGAAAGTCGGTGCGGATTTGGT
GACCCGCTGCAAGCGCAGACTCGATGCCATAAACGCTGCAGTATCCCCGGAGGAGTTGAACGTGCCAGGTTTCGACTTCC
ATGCTTTGGAGGGGAAACCGAAGCGGTACACGGTTTATGTGAATGGACCCTATTGCATCACCTTCGAGTGGCGTGAAGGA
GATGCCTGGCGCGTTGATCTGGAGAATTACCATTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11758.52 Da        Isoelectric Point: 5.6631

>AT32278 WP_126605156.1 NZ_AP018795:c1990619-1990302 [Acidithiobacillus ferridurans]
MDEMTVEQVDRTPTHPGEILREEVLPALDISVAEFARGLRVSRQTVHGILSERKGITPEMALRIGKYLGNGPGIWLRMQQ
AYDLTIAERRLAEELAAIHKPEQAA

Download         Length: 318 bp

>AT32278 NZ_AP018795:c1990619-1990302 [Acidithiobacillus ferridurans]
ATGGACGAAATGACCGTTGAGCAGGTGGACCGGACACCGACGCATCCGGGCGAGATATTGCGGGAGGAGGTACTGCCTGC
ACTGGATATCTCTGTAGCAGAGTTTGCCCGTGGCCTGCGGGTCTCGCGCCAGACCGTTCACGGCATCCTGTCCGAGCGCA
AAGGCATTACCCCAGAGATGGCCTTGCGTATCGGCAAGTATCTGGGTAACGGGCCGGGGATATGGCTACGCATGCAACAG
GCTTACGATTTGACCATTGCGGAACGTCGGTTGGCCGAAGAACTGGCGGCCATTCACAAGCCCGAGCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References