Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 152816..153238 Replicon plasmid pSK1144
Accession NZ_AP018785
Organism Escherichia coli strain SK1144

Toxin (Protein)


Gene name hok Uniprot ID B1VC78
Locus tag DAECLI1_RS25965 Protein ID WP_001302184.1
Coordinates 153080..153238 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 152816..153015 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAECLI1_RS25930 147993..148463 - 471 WP_024187138.1 hypothetical protein -
DAECLI1_RS25940 148765..149292 + 528 WP_000290833.1 single-stranded DNA-binding protein -
DAECLI1_RS25945 149349..149582 + 234 WP_000006018.1 DUF905 domain-containing protein -
DAECLI1_RS25950 149641..151599 + 1959 WP_001145501.1 ParB/RepB/Spo0J family partition protein -
DAECLI1_RS25955 151654..152088 + 435 WP_000845910.1 conjugation system SOS inhibitor PsiB -
DAECLI1_RS25960 152085..152804 + 720 WP_001276230.1 plasmid SOS inhibition protein A -
- 152816..153015 + 200 NuclAT_1 - Antitoxin
- 152816..153015 + 200 NuclAT_1 - Antitoxin
- 152816..153015 + 200 NuclAT_1 - Antitoxin
- 152816..153015 + 200 NuclAT_1 - Antitoxin
DAECLI1_RS25965 153080..153238 + 159 WP_001302184.1 type I toxin-antitoxin system Hok family toxin Toxin
DAECLI1_RS25985 154154..154441 + 288 WP_000107526.1 hypothetical protein -
DAECLI1_RS25990 154560..155381 + 822 WP_001234489.1 DUF945 domain-containing protein -
DAECLI1_RS25995 155678..156280 - 603 WP_001323326.1 transglycosylase SLT domain-containing protein -
DAECLI1_RS26000 156611..156994 + 384 WP_001151562.1 relaxosome protein TraM -
DAECLI1_RS26005 157188..157874 + 687 WP_000332487.1 PAS domain-containing protein -
DAECLI1_RS26010 157968..158195 + 228 WP_001254388.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - senB 1..169561 169561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-48)


Sequences


Toxin        


Download         Length: 53 a.a.        Molecular weight: 6108.35 Da        Isoelectric Point: 9.1977

>T32267 WP_001302184.1 NZ_AP018785:153080-153238 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Download         Length: 159 bp

>T32267 NZ_AP018785:153080-153238 [Escherichia coli]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 200 bp

>AT32267 NZ_AP018785:152816-153015 [Escherichia coli]
TCACAACGGATTGCCCGTAAACAGCCTGAATGAGCGAGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATAT
GGGCTATGATGTGCCCGGCGCTTGAGGTTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGG
ACAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References