32229

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 423476..424824 Replicon chromosome
Accession NZ_AP018783
Organism Haemophilus influenzae strain CHBN-V-3 isolate 15H03

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K6J71_RS02160 Protein ID WP_005667626.1
Coordinates 423793..424824 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag K6J71_RS02155 Protein ID WP_005667629.1
Coordinates 423476..423796 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J71_RS02115 (CHBNV3_04050) 418906..419184 + 279 WP_005661211.1 cell division protein FtsB -
K6J71_RS02120 (CHBNV3_04060) 419184..419861 + 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J71_RS02125 (CHBNV3_04070) 419858..420334 + 477 WP_005667638.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J71_RS02130 (CHBNV3_04080) 420632..421066 - 435 WP_005667636.1 D-aminoacyl-tRNA deacylase -
K6J71_RS02135 (CHBNV3_04090) 421063..421503 - 441 WP_005667635.1 FMN-binding protein MioC -
K6J71_RS02140 (CHBNV3_04100) 421600..421818 - 219 WP_005650820.1 cell division protein ZapB -
K6J71_RS02145 (CHBNV3_04110) 421980..422981 + 1002 WP_005667633.1 class II fructose-bisphosphatase -
K6J71_RS02150 (CHBNV3_04120) 423180..423488 + 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
K6J71_RS02155 (CHBNV3_04130) 423476..423796 + 321 WP_005667629.1 HipA N-terminal domain-containing protein Antitoxin
K6J71_RS02160 (CHBNV3_04140) 423793..424824 + 1032 WP_005667626.1 HipA domain-containing protein Toxin
K6J71_RS02165 (CHBNV3_04150) 424907..426565 - 1659 WP_005667625.1 thiol reductant ABC exporter subunit CydC -
K6J71_RS02170 (CHBNV3_04160) 426558..428303 - 1746 WP_221282174.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39869.52 Da        Isoelectric Point: 6.4431

>T32229 WP_005667626.1 NZ_AP018783:423793-424824 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSINQQ
GNYILKPSPEEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKIAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFYTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLHEPEL

Download         Length: 1032 bp

>T32229 NZ_AP018783:423793-424824 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCATAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCACATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAAATTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTTA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCATTACTTAACCTATTACATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12457.11 Da        Isoelectric Point: 5.9670

>AT32229 WP_005667629.1 NZ_AP018783:423476-423796 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32229 NZ_AP018783:423476-423796 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References