Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 389829..391177 Replicon chromosome
Accession NZ_AP018782
Organism Haemophilus influenzae strain CHBN-V-2 isolate 13H37

Toxin (Protein)


Gene name HipT Uniprot ID A0A806EDV8
Locus tag K6J59_RS01925 Protein ID WP_020910208.1
Coordinates 390146..391177 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A806DF96
Locus tag K6J59_RS01920 Protein ID WP_020910207.1
Coordinates 389829..390149 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J59_RS01880 (CHBNV2_03520) 385243..385521 + 279 WP_005661211.1 cell division protein FtsB -
K6J59_RS01885 (CHBNV2_03530) 385521..386198 + 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J59_RS01890 (CHBNV2_03540) 386195..386671 + 477 WP_005650817.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J59_RS01895 (CHBNV2_03550) 386984..387418 - 435 WP_005650818.1 D-aminoacyl-tRNA deacylase -
K6J59_RS01900 (CHBNV2_03560) 387415..387855 - 441 WP_020910205.1 FMN-binding protein MioC -
K6J59_RS01905 (CHBNV2_03570) 387952..388170 - 219 WP_005650820.1 cell division protein ZapB -
K6J59_RS01910 (CHBNV2_03580) 388332..389333 + 1002 WP_020910206.1 class II fructose-bisphosphatase -
K6J59_RS01915 (CHBNV2_03590) 389533..389841 + 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
K6J59_RS01920 (CHBNV2_03600) 389829..390149 + 321 WP_020910207.1 HipA N-terminal domain-containing protein Antitoxin
K6J59_RS01925 (CHBNV2_03610) 390146..391177 + 1032 WP_020910208.1 HipA domain-containing protein Toxin
K6J59_RS01930 (CHBNV2_03620) 391260..392918 - 1659 WP_020910209.1 thiol reductant ABC exporter subunit CydC -
K6J59_RS01935 (CHBNV2_03630) 392911..394656 - 1746 WP_020910210.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39886.46 Da        Isoelectric Point: 6.2886

>T32220 WP_020910208.1 NZ_AP018782:390146-391177 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELEFDVPENGLVPFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T32220 NZ_AP018782:390146-391177 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGAATTTGACGTGCCAGAAAATGGTTTAGTTCCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTAAGTTATGAGCGCGTTGCTAAGTTTATTTTACAACACACCGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGCGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATAGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12438.06 Da        Isoelectric Point: 5.8850

>AT32220 WP_020910207.1 NZ_AP018782:389829-390149 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32220 NZ_AP018782:389829-390149 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EDV8

Antitoxin

Source ID Structure
AlphaFold DB A0A806DF96

References