32212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 393810..395158 Replicon chromosome
Accession NZ_AP018781
Organism Haemophilus influenzae strain CHBN-V-1 isolate 13H43

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CHBNTHi_RS01945 Protein ID WP_110437461.1
Coordinates 394127..395158 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CHBNTHi_RS01940 Protein ID WP_110437462.1
Coordinates 393810..394130 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHBNTHi_RS01900 (CHBNV1_03570) 389230..389508 + 279 WP_005658968.1 cell division protein FtsB -
CHBNTHi_RS01905 (CHBNV1_03580) 389508..390185 + 678 WP_110437464.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
CHBNTHi_RS01910 (CHBNV1_03590) 390182..390658 + 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
CHBNTHi_RS01915 (CHBNV1_03600) 390963..391397 - 435 WP_005650818.1 D-aminoacyl-tRNA deacylase -
CHBNTHi_RS01920 (CHBNV1_03610) 391394..391834 - 441 WP_020910205.1 FMN-binding protein MioC -
CHBNTHi_RS01925 (CHBNV1_03620) 391932..392150 - 219 WP_005650820.1 cell division protein ZapB -
CHBNTHi_RS01930 (CHBNV1_03630) 392312..393313 + 1002 WP_110437463.1 class II fructose-bisphosphatase -
CHBNTHi_RS01935 (CHBNV1_03640) 393514..393822 + 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
CHBNTHi_RS01940 (CHBNV1_03650) 393810..394130 + 321 WP_110437462.1 HipA N-terminal domain-containing protein Antitoxin
CHBNTHi_RS01945 (CHBNV1_03660) 394127..395158 + 1032 WP_110437461.1 HipA domain-containing protein Toxin
CHBNTHi_RS01950 (CHBNV1_03670) 395243..396901 - 1659 WP_110437460.1 thiol reductant ABC exporter subunit CydC -
CHBNTHi_RS01955 (CHBNV1_03680) 396894..398639 - 1746 WP_110437459.1 ABC transporter ATP-binding protein/permease -
CHBNTHi_RS01960 (CHBNV1_03690) 398692..398856 - 165 WP_050848769.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39815.41 Da        Isoelectric Point: 6.7268

>T32212 WP_110437461.1 NZ_AP018781:394127-395158 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATIRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T32212 NZ_AP018781:394127-395158 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGCACAAAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATACGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTAAGTTATGAGCGCGTTGCTAAGTTTATTTTACAACACACCGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGCGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATAGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12440.12 Da        Isoelectric Point: 6.3254

>AT32212 WP_110437462.1 NZ_AP018781:393810-394130 [Haemophilus influenzae]
MRNLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32212 NZ_AP018781:393810-394130 [Haemophilus influenzae]
ATGCGCAATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References