Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1206822..1207461 Replicon chromosome
Accession NZ_AP018780
Organism Haemophilus influenzae strain CHBN-IV-1 isolate 13H36

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6J73_RS05880 Protein ID WP_105872812.1
Coordinates 1206822..1207127 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6J73_RS05885 Protein ID WP_050848570.1
Coordinates 1207138..1207461 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J73_RS05860 (CHBNIV1_10960) 1202251..1204290 - 2040 WP_221252819.1 excinuclease ABC subunit UvrB -
K6J73_RS05870 (CHBNIV1_10970) 1204905..1205873 - 969 WP_221252820.1 zinc transporter permease subunit ZevB -
K6J73_RS05875 (CHBNIV1_10980) 1205876..1206496 - 621 WP_221252821.1 zinc transporter binding subunit ZevA -
K6J73_RS05880 (CHBNIV1_10990) 1206822..1207127 + 306 WP_105872812.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J73_RS05885 (CHBNIV1_11000) 1207138..1207461 + 324 WP_050848570.1 HigA family addiction module antitoxin Antitoxin
K6J73_RS05890 (CHBNIV1_11010) 1207624..1209294 + 1671 WP_005663485.1 energy-dependent translational throttle protein EttA -
K6J73_RS05895 (CHBNIV1_11020) 1209356..1209697 + 342 WP_005652996.1 SirB2 family protein -
K6J73_RS05900 (CHBNIV1_11030) 1209702..1211672 + 1971 WP_221252822.1 GNAT family N-acetyltransferase -
K6J73_RS05905 (CHBNIV1_11040) 1211669..1211842 + 174 WP_221252823.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12195.81 Da        Isoelectric Point: 9.1259

>T32208 WP_105872812.1 NZ_AP018780:1206822-1207127 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDAHSKIPSNLSKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

>T32208 NZ_AP018780:1206822-1207127 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATGCTCATAGTAAGAT
TCCTTCTAATTTATCTAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCACTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTGAATAAACAATATCGTTTG
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTGTATTTAGATCCACATTCTTATAATTTATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12247.06 Da        Isoelectric Point: 8.8251

>AT32208 WP_050848570.1 NZ_AP018780:1207138-1207461 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKINDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKAFDTTPEFWLNLQTRIDLWNL
EHNKRFQQSLANVKSALHRHGTSAFAM

Download         Length: 324 bp

>AT32208 NZ_AP018780:1207138-1207461 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGCGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAATGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGCATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGAACCTT
GAACACAATAAACGTTTTCAACAAAGCCTTGCGAATGTTAAGTCCGCTCTACATCGGCATGGCACTTCTGCATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References