32198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 330492..331840 Replicon chromosome
Accession NZ_AP018779
Organism Haemophilus influenzae strain CHBN-III-8 isolate 10H15

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K6J62_RS01665 Protein ID WP_110432205.1
Coordinates 330809..331840 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A806DF96
Locus tag K6J62_RS01660 Protein ID WP_020910207.1
Coordinates 330492..330812 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J62_RS01620 (CHBNIII8_03100) 325924..326202 + 279 WP_005661211.1 cell division protein FtsB -
K6J62_RS01625 (CHBNIII8_03110) 326202..326879 + 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J62_RS01630 (CHBNIII8_03120) 326876..327352 + 477 WP_005661209.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J62_RS01635 (CHBNIII8_03130) 327650..328084 - 435 WP_013526377.1 D-aminoacyl-tRNA deacylase -
K6J62_RS01640 (CHBNIII8_03140) 328081..328521 - 441 WP_005694621.1 FMN-binding protein MioC -
K6J62_RS01645 (CHBNIII8_03150) 328615..328833 - 219 WP_005650820.1 cell division protein ZapB -
K6J62_RS01650 (CHBNIII8_03160) 328995..329996 + 1002 WP_005687920.1 class II fructose-bisphosphatase -
K6J62_RS01655 (CHBNIII8_03170) 330196..330504 + 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
K6J62_RS01660 (CHBNIII8_03180) 330492..330812 + 321 WP_020910207.1 HipA N-terminal domain-containing protein Antitoxin
K6J62_RS01665 (CHBNIII8_03190) 330809..331840 + 1032 WP_110432205.1 HipA domain-containing protein Toxin
K6J62_RS01670 (CHBNIII8_03200) 331924..333582 - 1659 WP_110432204.1 thiol reductant ABC exporter subunit CydC -
K6J62_RS01675 (CHBNIII8_03210) 333575..335320 - 1746 WP_110432203.1 ABC transporter ATP-binding protein/permease -
K6J62_RS08765 335653..335703 + 51 Protein_326 hypothetical protein -
K6J62_RS08780 335751..336135 + 385 Protein_327 TonB-dependent receptor plug domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39723.18 Da        Isoelectric Point: 5.9671

>T32198 WP_110432205.1 NZ_AP018779:330809-331840 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTAIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQQEIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSLYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLTLLNVLNEPEL

Download         Length: 1032 bp

>T32198 NZ_AP018779:330809-331840 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAACTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAACAGCGATTCATCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACAAGAGATTTTCCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTATCGGTGTCGCTCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGAGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTCGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGTGTACTGAAAACTTATCGCAAGCGTTTAACGTTACTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12438.06 Da        Isoelectric Point: 5.8850

>AT32198 WP_020910207.1 NZ_AP018779:330492-330812 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32198 NZ_AP018779:330492-330812 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806DF96

References