Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 329551..330899 Replicon chromosome
Accession NZ_AP018778
Organism Haemophilus influenzae strain CHBN-III-7 isolate 15H01

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K6J60_RS01660 Protein ID WP_118807949.1
Coordinates 329868..330899 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag K6J60_RS01655 Protein ID WP_118807950.1
Coordinates 329551..329871 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J60_RS01610 (CHBNIII7_03090) 324781..325059 + 279 WP_005665661.1 cell division protein FtsB -
K6J60_RS01615 (CHBNIII7_03100) 325059..325736 + 678 WP_118807954.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J60_RS01620 (CHBNIII7_03110) 325733..326209 + 477 WP_021034585.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J60_RS01625 (CHBNIII7_03120) 326279..326446 - 168 WP_192885231.1 hypothetical protein -
K6J60_RS01630 (CHBNIII7_03130) 326705..327139 - 435 WP_050847478.1 D-aminoacyl-tRNA deacylase -
K6J60_RS01635 (CHBNIII7_03140) 327136..327576 - 441 WP_118807953.1 FMN-binding protein MioC -
K6J60_RS01640 (CHBNIII7_03150) 327674..327892 - 219 WP_005650820.1 cell division protein ZapB -
K6J60_RS01645 (CHBNIII7_03160) 328054..329055 + 1002 WP_118807952.1 class II fructose-bisphosphatase -
K6J60_RS01650 (CHBNIII7_03170) 329255..329563 + 309 WP_118807951.1 helix-turn-helix transcriptional regulator -
K6J60_RS01655 (CHBNIII7_03180) 329551..329871 + 321 WP_118807950.1 HipA N-terminal domain-containing protein Antitoxin
K6J60_RS01660 (CHBNIII7_03190) 329868..330899 + 1032 WP_118807949.1 HipA domain-containing protein Toxin
K6J60_RS01665 (CHBNIII7_03200) 330983..332641 - 1659 WP_221267374.1 thiol reductant ABC exporter subunit CydC -
K6J60_RS01670 (CHBNIII7_03210) 332634..334379 - 1746 WP_221267375.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39928.44 Da        Isoelectric Point: 6.3724

>T32192 WP_118807949.1 NZ_AP018778:329868-330899 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELEFDVPENGLVPFADEQNHKEFAFVIKRFDRDEQQTAIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
ETFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T32192 NZ_AP018778:329868-330899 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTGCATTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGAATTTGACGTGCCAGAAAATGGTTTAGTTCCTTTTGCTGACGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAACAGCGATTCATCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAACAACGAGAAATTTTTCGCCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAATAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTACCCT
GAAACATTTAATTCAACACTACTTGCCTTACCATTGTTAGCGAGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGTGTACTGAAAACTTATCGCAAGCGTTTAGCGTTACTTAACCTATTAAATGAACCTGAGCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12470.15 Da        Isoelectric Point: 6.3254

>AT32192 WP_118807950.1 NZ_AP018778:329551-329871 [Haemophilus influenzae]
MRNLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32192 NZ_AP018778:329551-329871 [Haemophilus influenzae]
ATGCGCAATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References