Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1596209..1596848 Replicon chromosome
Accession NZ_AP018777
Organism Haemophilus influenzae strain CHBN-III-6 isolate 13H31

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6J69_RS07970 Protein ID WP_105872812.1
Coordinates 1596543..1596848 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6J69_RS07965 Protein ID WP_050848570.1
Coordinates 1596209..1596532 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J69_RS07945 (CHBNIII6_15250) 1591828..1592001 - 174 WP_005657572.1 DUF5363 domain-containing protein -
K6J69_RS07950 (CHBNIII6_15260) 1591998..1593968 - 1971 WP_044330238.1 GNAT family N-acetyltransferase -
K6J69_RS07955 (CHBNIII6_15270) 1593973..1594314 - 342 WP_050846956.1 SirB2 family protein -
K6J69_RS07960 (CHBNIII6_15280) 1594376..1596046 - 1671 WP_085000141.1 energy-dependent translational throttle protein EttA -
K6J69_RS07965 (CHBNIII6_15290) 1596209..1596532 - 324 WP_050848570.1 HigA family addiction module antitoxin Antitoxin
K6J69_RS07970 (CHBNIII6_15300) 1596543..1596848 - 306 WP_105872812.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J69_RS07975 (CHBNIII6_15310) 1597174..1597794 + 621 WP_110430468.1 zinc transporter binding subunit ZevA -
K6J69_RS07980 (CHBNIII6_15320) 1597797..1598771 + 975 WP_110430469.1 zinc transporter permease subunit ZevB -
K6J69_RS09470 1598947..1599027 - 81 WP_231902324.1 hypothetical protein -
K6J69_RS07985 (CHBNIII6_15330) 1599071..1599520 - 450 WP_238144017.1 ESPR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12195.81 Da        Isoelectric Point: 9.1259

>T32189 WP_105872812.1 NZ_AP018777:c1596848-1596543 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDAHSKIPSNLSKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

>T32189 NZ_AP018777:c1596848-1596543 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATGCTCATAGTAAGAT
TCCTTCTAATTTATCTAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCACTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTGAATAAACAATATCGTTTG
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTGTATTTAGATCCACATTCTTATAATTTATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12247.06 Da        Isoelectric Point: 8.8251

>AT32189 WP_050848570.1 NZ_AP018777:c1596532-1596209 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKINDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKAFDTTPEFWLNLQTRIDLWNL
EHNKRFQQSLANVKSALHRHGTSAFAM

Download         Length: 324 bp

>AT32189 NZ_AP018777:c1596532-1596209 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGCGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAATGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGCATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGAACCTT
GAACACAATAAACGTTTTCAACAAAGCCTTGCGAATGTTAAGTCCGCTCTACATCGGCATGGCACTTCTGCATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References