Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1382156..1382825 Replicon chromosome
Accession NZ_AP018777
Organism Haemophilus influenzae strain CHBN-III-6 isolate 13H31

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag K6J69_RS06950 Protein ID WP_015701504.1
Coordinates 1382156..1382539 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag K6J69_RS06955 Protein ID WP_005651224.1
Coordinates 1382523..1382825 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J69_RS06915 (CHBNIII6_13220) 1378916..1379239 + 324 WP_005651203.1 DUF2190 family protein -
K6J69_RS06920 (CHBNIII6_13230) 1379220..1379531 + 312 WP_005651204.1 hypothetical protein -
K6J69_RS06925 (CHBNIII6_13240) 1379534..1380064 + 531 WP_110431017.1 phage tail protein -
K6J69_RS06930 (CHBNIII6_13250) 1380112..1380483 + 372 WP_230304754.1 phage minor tail U family protein -
K6J69_RS06935 (CHBNIII6_13260) 1380486..1381136 + 651 WP_050846007.1 hypothetical protein -
K6J69_RS06940 1381411..1381818 + 408 Protein_1324 hypothetical protein -
K6J69_RS06945 (CHBNIII6_13300) 1381863..1382087 + 225 WP_038440708.1 DUF4035 domain-containing protein -
K6J69_RS06950 (CHBNIII6_13310) 1382156..1382539 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J69_RS06955 (CHBNIII6_13320) 1382523..1382825 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
K6J69_RS06960 (CHBNIII6_13330) 1382841..1383077 + 237 WP_101494098.1 hypothetical protein -
K6J69_RS06965 (CHBNIII6_13340) 1383129..1386521 + 3393 WP_110431018.1 tape measure protein -
K6J69_RS06970 (CHBNIII6_13350) 1386530..1386862 + 333 WP_110431019.1 phage tail protein -
K6J69_RS06975 (CHBNIII6_13360) 1386954..1387112 + 159 WP_005651234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1355992..1399184 43192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T32188 WP_015701504.1 NZ_AP018777:1382156-1382539 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T32188 NZ_AP018777:1382156-1382539 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT32188 WP_005651224.1 NZ_AP018777:1382523-1382825 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT32188 NZ_AP018777:1382523-1382825 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References