32179

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 358323..359671 Replicon chromosome
Accession NZ_AP018776
Organism Haemophilus influenzae strain CHBN-III-5 isolate 13H30

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K6J67_RS01795 Protein ID WP_050822754.1
Coordinates 358640..359671 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag K6J67_RS01790 Protein ID WP_048954894.1
Coordinates 358323..358643 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J67_RS01750 (CHBNIII5_03380) 353738..354016 + 279 WP_005665661.1 cell division protein FtsB -
K6J67_RS01755 (CHBNIII5_03390) 354016..354693 + 678 WP_050822756.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J67_RS01760 (CHBNIII5_03400) 354690..355166 + 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J67_RS01765 (CHBNIII5_03410) 355478..355912 - 435 WP_005667636.1 D-aminoacyl-tRNA deacylase -
K6J67_RS01770 (CHBNIII5_03420) 355909..356349 - 441 WP_005667635.1 FMN-binding protein MioC -
K6J67_RS01775 (CHBNIII5_03430) 356446..356664 - 219 WP_005650820.1 cell division protein ZapB -
K6J67_RS01780 (CHBNIII5_03440) 356826..357827 + 1002 WP_005690169.1 class II fructose-bisphosphatase -
K6J67_RS01785 (CHBNIII5_03450) 358027..358335 + 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
K6J67_RS01790 (CHBNIII5_03460) 358323..358643 + 321 WP_048954894.1 HipA N-terminal domain-containing protein Antitoxin
K6J67_RS01795 (CHBNIII5_03470) 358640..359671 + 1032 WP_050822754.1 HipA domain-containing protein Toxin
K6J67_RS01800 (CHBNIII5_03480) 359754..361412 - 1659 WP_110431390.1 ABC transporter ATP-binding protein -
K6J67_RS01805 (CHBNIII5_03490) 361405..363150 - 1746 WP_050822749.1 ABC transporter ATP-binding protein/permease -
K6J67_RS08945 363490..363633 + 144 WP_246588187.1 PT domain-containing protein -
K6J67_RS08950 363575..363985 + 411 Protein_353 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39795.39 Da        Isoelectric Point: 6.3487

>T32179 WP_050822754.1 NZ_AP018776:358640-359671 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T32179 NZ_AP018776:358640-359671 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAAAATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACCGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTACAACACACCGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGTGCGAGAAGAGGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12433.09 Da        Isoelectric Point: 6.2114

>AT32179 WP_048954894.1 NZ_AP018776:358323-358643 [Haemophilus influenzae]
MRNLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32179 NZ_AP018776:358323-358643 [Haemophilus influenzae]
ATGCGCAATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References