32170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 356594..357942 Replicon chromosome
Accession NZ_AP018775
Organism Haemophilus influenzae strain CHBN-III-4 isolate 12H35

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K6J64_RS01815 Protein ID WP_044345221.1
Coordinates 356911..357942 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2R3FM14
Locus tag K6J64_RS01810 Protein ID WP_005687922.1
Coordinates 356594..356914 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J64_RS01770 (CHBNIII4_03420) 352022..352300 + 279 WP_005665661.1 cell division protein FtsB -
K6J64_RS01775 (CHBNIII4_03430) 352300..352977 + 678 WP_014551114.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J64_RS01780 (CHBNIII4_03440) 352974..353450 + 477 WP_014551115.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J64_RS01785 (CHBNIII4_03450) 353752..354186 - 435 WP_005687917.1 D-aminoacyl-tRNA deacylase -
K6J64_RS01790 (CHBNIII4_03460) 354183..354623 - 441 WP_005687918.1 FMN-binding protein MioC -
K6J64_RS01795 (CHBNIII4_03470) 354717..354935 - 219 WP_005650820.1 cell division protein ZapB -
K6J64_RS01800 (CHBNIII4_03480) 355097..356098 + 1002 WP_005687920.1 class II fructose-bisphosphatase -
K6J64_RS01805 (CHBNIII4_03490) 356298..356606 + 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
K6J64_RS01810 (CHBNIII4_03500) 356594..356914 + 321 WP_005687922.1 HipA N-terminal domain-containing protein Antitoxin
K6J64_RS01815 (CHBNIII4_03510) 356911..357942 + 1032 WP_044345221.1 HipA domain-containing protein Toxin
K6J64_RS01820 (CHBNIII4_03520) 358026..359684 - 1659 WP_048946893.1 thiol reductant ABC exporter subunit CydC -
K6J64_RS01825 (CHBNIII4_03530) 359677..361422 - 1746 WP_048946894.1 ABC transporter ATP-binding protein/permease -
K6J64_RS08975 361778..361933 + 156 WP_233993456.1 PT domain-containing protein -
K6J64_RS08980 361869..362288 + 420 Protein_362 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39860.37 Da        Isoelectric Point: 6.5052

>T32170 WP_044345221.1 NZ_AP018775:356911-357942 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLTLLNVLNEPEL

Download         Length: 1032 bp

>T32170 NZ_AP018775:356911-357942 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGACTACAGCACAAAAGGTTTACATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGGGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAACGTTACTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12407.09 Da        Isoelectric Point: 5.9670

>AT32170 WP_005687922.1 NZ_AP018775:356594-356914 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32170 NZ_AP018775:356594-356914 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3FM14

References