Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 359528..360876 Replicon chromosome
Accession NZ_AP018774
Organism Haemophilus influenzae strain CHBN-III-3 isolate 13H42

Toxin (Protein)


Gene name HipT Uniprot ID A0A5C6GXP8
Locus tag K6J70_RS01795 Protein ID WP_012054635.1
Coordinates 359845..360876 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2R3FM14
Locus tag K6J70_RS01790 Protein ID WP_005687922.1
Coordinates 359528..359848 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J70_RS01750 (CHBNIII3_03380) 354956..355234 + 279 WP_005665661.1 cell division protein FtsB -
K6J70_RS01755 (CHBNIII3_03390) 355234..355911 + 678 WP_012054634.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J70_RS01760 (CHBNIII3_03400) 355908..356384 + 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J70_RS01765 (CHBNIII3_03410) 356686..357120 - 435 WP_005687917.1 D-aminoacyl-tRNA deacylase -
K6J70_RS01770 (CHBNIII3_03420) 357117..357557 - 441 WP_005687918.1 FMN-binding protein MioC -
K6J70_RS01775 (CHBNIII3_03430) 357651..357869 - 219 WP_005650820.1 cell division protein ZapB -
K6J70_RS01780 (CHBNIII3_03440) 358031..359032 + 1002 WP_005687920.1 class II fructose-bisphosphatase -
K6J70_RS01785 (CHBNIII3_03450) 359232..359540 + 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
K6J70_RS01790 (CHBNIII3_03460) 359528..359848 + 321 WP_005687922.1 HipA N-terminal domain-containing protein Antitoxin
K6J70_RS01795 (CHBNIII3_03470) 359845..360876 + 1032 WP_012054635.1 HipA domain-containing protein Toxin
K6J70_RS01800 (CHBNIII3_03480) 360960..362618 - 1659 WP_012054636.1 thiol reductant ABC exporter subunit CydC -
K6J70_RS01805 (CHBNIII3_03490) 362611..364356 - 1746 WP_012054637.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39830.34 Da        Isoelectric Point: 6.5052

>T32161 WP_012054635.1 NZ_AP018774:359845-360876 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

>T32161 NZ_AP018774:359845-360876 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGACTACAGCACAAAAGGTTTACATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGGGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCATTACTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12407.09 Da        Isoelectric Point: 5.9670

>AT32161 WP_005687922.1 NZ_AP018774:359528-359848 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32161 NZ_AP018774:359528-359848 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C6GXP8

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3FM14

References