Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1243691..1244330 Replicon chromosome
Accession NZ_AP018771
Organism Haemophilus influenzae strain CHBN-II-8 isolate 10H27

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6J66_RS06085 Protein ID WP_110442641.1
Coordinates 1243691..1243996 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6J66_RS06090 Protein ID WP_005650217.1
Coordinates 1244007..1244330 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J66_RS06065 (CHBNII8_11430) 1239121..1241160 - 2040 WP_038439719.1 excinuclease ABC subunit UvrB -
K6J66_RS06075 (CHBNII8_11440) 1241775..1242743 - 969 WP_014550701.1 zinc transporter permease subunit ZevB -
K6J66_RS06080 (CHBNII8_11450) 1242746..1243366 - 621 WP_038439720.1 zinc transporter binding subunit ZevA -
K6J66_RS06085 (CHBNII8_11460) 1243691..1243996 + 306 WP_110442641.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J66_RS06090 (CHBNII8_11470) 1244007..1244330 + 324 WP_005650217.1 HigA family addiction module antitoxin Antitoxin
K6J66_RS06095 (CHBNII8_11480) 1244493..1246163 + 1671 WP_005663485.1 energy-dependent translational throttle protein EttA -
K6J66_RS06100 (CHBNII8_11490) 1246225..1246566 + 342 WP_038439721.1 SirB2 family protein -
K6J66_RS06105 (CHBNII8_11500) 1246571..1248415 + 1845 WP_038439722.1 GNAT family N-acetyltransferase -
K6J66_RS06110 (CHBNII8_11510) 1248412..1248585 + 174 WP_005652999.1 DUF5363 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12287.86 Da        Isoelectric Point: 8.3260

>T32135 WP_110442641.1 NZ_AP018771:1243691-1243996 [Haemophilus influenzae]
MFNLNREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

>T32135 NZ_AP018771:1243691-1243996 [Haemophilus influenzae]
ATGTTTAATTTAAATCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGAGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT32135 WP_005650217.1 NZ_AP018771:1244007-1244330 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp

>AT32135 NZ_AP018771:1244007-1244330 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACACTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAACCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References