Detailed information of TA system TA032133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 342200..343548
• Replicon: chromosome
• Accession: NZ_AP018771
• Organism: Haemophilus influenzae strain CHBN-II-8 isolate 10H27

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: K6J66_RS01715
• Protein ID: WP_038439531.1
• Coordinates: 342517..343548 (+)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A806DF96
• Locus tag: K6J66_RS01710
• Protein ID: WP_020910207.1
• Coordinates: 342200..342520 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J66_RS01670 (CHBNII8_03220)	337628..337906	+	279	WP_005665661.1	cell division protein FtsB	-
K6J66_RS01675 (CHBNII8_03230)	337906..338583	+	678	WP_005655267.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
K6J66_RS01680 (CHBNII8_03240)	338580..339056	+	477	WP_005661209.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
K6J66_RS01685 (CHBNII8_03250)	339358..339792	-	435	WP_038439533.1	D-aminoacyl-tRNA deacylase	-
K6J66_RS01690 (CHBNII8_03260)	339789..340229	-	441	WP_005667635.1	FMN-binding protein MioC	-
K6J66_RS01695 (CHBNII8_03270)	340323..340541	-	219	WP_005650820.1	cell division protein ZapB	-
K6J66_RS01700 (CHBNII8_03280)	340703..341704	+	1002	WP_038439532.1	class II fructose-bisphosphatase	-
K6J66_RS01705 (CHBNII8_03290)	341904..342212	+	309	WP_005661200.1	helix-turn-helix transcriptional regulator	-
K6J66_RS01710 (CHBNII8_03300)	342200..342520	+	321	WP_020910207.1	HipA N-terminal domain-containing protein	Antitoxin
K6J66_RS01715 (CHBNII8_03310)	342517..343548	+	1032	WP_038439531.1	HipA domain-containing protein	Toxin
K6J66_RS01720 (CHBNII8_03320)	343633..345291	-	1659	WP_110442610.1	thiol reductant ABC exporter subunit CydC	-
K6J66_RS01725 (CHBNII8_03330)	345284..347029	-	1746	WP_110442609.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39935.58 Da
• Isoelectric Point: 6.4335

>T32133 WP_038439531.1 NZ_AP018771:342517-343548 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNDTLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLFLLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T32133 NZ_AP018771:342517-343548 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAACTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGTGCGAGAAGAGGGTAATGACACACTAGCCAAAGGATTTAA
TACTCAATACGGCGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTATTTTTGCTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12438.06 Da
• Isoelectric Point: 5.8850

>AT32133 WP_020910207.1 NZ_AP018771:342200-342520 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT32133 NZ_AP018771:342200-342520 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A806DF96