Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 683734..684403 Replicon chromosome
Accession NZ_AP018770
Organism Haemophilus influenzae strain CHBN-II-7 isolate 13H35

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag K6J57_RS03475 Protein ID WP_015701504.1
Coordinates 683734..684117 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag K6J57_RS03480 Protein ID WP_005651224.1
Coordinates 684101..684403 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J57_RS03440 (CHBNII7_06540) 680494..680817 + 324 WP_042593431.1 DUF2190 family protein -
K6J57_RS03445 (CHBNII7_06550) 680798..681109 + 312 WP_042611831.1 hypothetical protein -
K6J57_RS03450 (CHBNII7_06560) 681112..681633 + 522 WP_042593432.1 phage tail protein -
K6J57_RS03455 (CHBNII7_06570) 681690..682061 + 372 WP_230304754.1 phage minor tail U family protein -
K6J57_RS03460 (CHBNII7_06580) 682064..682714 + 651 WP_038440702.1 hypothetical protein -
K6J57_RS03465 (CHBNII7_06600) 682989..683396 + 408 WP_038440705.1 hypothetical protein -
K6J57_RS03470 (CHBNII7_06610) 683441..683665 + 225 WP_038440708.1 DUF4035 domain-containing protein -
K6J57_RS03475 (CHBNII7_06620) 683734..684117 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J57_RS03480 (CHBNII7_06630) 684101..684403 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
K6J57_RS03485 (CHBNII7_06640) 684419..684655 + 237 WP_101494098.1 hypothetical protein -
K6J57_RS03490 (CHBNII7_06650) 684707..688099 + 3393 WP_221266040.1 tape measure protein -
K6J57_RS03495 (CHBNII7_06660) 688108..688440 + 333 WP_038440713.1 phage tail protein -
K6J57_RS03500 (CHBNII7_06670) 688707..688892 + 186 WP_042593434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 652963..699033 46070


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T32128 WP_015701504.1 NZ_AP018770:683734-684117 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T32128 NZ_AP018770:683734-684117 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT32128 WP_005651224.1 NZ_AP018770:684101-684403 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT32128 NZ_AP018770:684101-684403 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References