Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 371671..373019 Replicon chromosome
Accession NZ_AP018768
Organism Haemophilus influenzae strain CHBN-II-5 isolate 13H40

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K6J56_RS01835 Protein ID WP_044364635.1
Coordinates 371988..373019 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A806DF96
Locus tag K6J56_RS01830 Protein ID WP_020910207.1
Coordinates 371671..371991 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J56_RS01790 (CHBNII5_03350) 367084..367362 + 279 WP_005661211.1 cell division protein FtsB -
K6J56_RS01795 (CHBNII5_03360) 367362..368039 + 678 WP_011272161.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J56_RS01800 (CHBNII5_03370) 368036..368512 + 477 WP_006995249.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J56_RS01805 (CHBNII5_03380) 368819..369253 - 435 WP_005650818.1 D-aminoacyl-tRNA deacylase -
K6J56_RS01810 (CHBNII5_03390) 369250..369690 - 441 WP_005667635.1 FMN-binding protein MioC -
K6J56_RS01815 (CHBNII5_03400) 369789..370007 - 219 WP_005650820.1 cell division protein ZapB -
K6J56_RS01820 (CHBNII5_03410) 370169..371170 + 1002 WP_011272160.1 class II fructose-bisphosphatase -
K6J56_RS01825 (CHBNII5_03420) 371375..371683 + 309 WP_044364634.1 helix-turn-helix transcriptional regulator -
K6J56_RS01830 (CHBNII5_03430) 371671..371991 + 321 WP_020910207.1 HipA N-terminal domain-containing protein Antitoxin
K6J56_RS01835 (CHBNII5_03440) 371988..373019 + 1032 WP_044364635.1 HipA domain-containing protein Toxin
K6J56_RS01840 (CHBNII5_03450) 373102..374760 - 1659 WP_044364637.1 thiol reductant ABC exporter subunit CydC -
K6J56_RS01845 (CHBNII5_03460) 374753..376498 - 1746 WP_044364639.1 ABC transporter ATP-binding protein/permease -
K6J56_RS01850 (CHBNII5_03470) 376547..376711 - 165 WP_044364641.1 hypothetical protein -
K6J56_RS01855 376764..376928 - 165 WP_044364643.1 hypothetical protein -
K6J56_RS08865 377295..377438 + 144 WP_246593286.1 PT domain-containing protein -
K6J56_RS08870 377385..377793 + 409 Protein_353 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39847.43 Da        Isoelectric Point: 6.4335

>T32114 WP_044364635.1 NZ_AP018768:371988-373019 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNDTLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

>T32114 NZ_AP018768:371988-373019 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAACTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGTGCGAGAAGAGGGTAATGACACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCGTTACTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12438.06 Da        Isoelectric Point: 5.8850

>AT32114 WP_020910207.1 NZ_AP018768:371671-371991 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32114 NZ_AP018768:371671-371991 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806DF96

References