Detailed information of TA system TA032106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 374571..375919
• Replicon: chromosome
• Accession: NZ_AP018767
• Organism: Haemophilus influenzae strain CHBN-II-4 isolate 13H33

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: K6J55_RS01865
• Protein ID: WP_048942801.1
• Coordinates: 374888..375919 (+)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: Q4QMQ1
• Locus tag: K6J55_RS01860
• Protein ID: WP_011272158.1
• Coordinates: 374571..374891 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J55_RS01815 (CHBNII4_03370)	369790..370068	+	279	WP_105886796.1	cell division protein FtsB	-
K6J55_RS01820 (CHBNII4_03380)	370068..370745	+	678	WP_110431195.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
K6J55_RS01825 (CHBNII4_03390)	370742..371218	+	477	WP_005658971.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
K6J55_RS01830 (CHBNII4_03400)	371288..371455	-	168	WP_181145040.1	hypothetical protein	-
K6J55_RS01835 (CHBNII4_03410)	371720..372154	-	435	WP_221257438.1	D-aminoacyl-tRNA deacylase	-
K6J55_RS01840 (CHBNII4_03420)	372151..372591	-	441	WP_221257439.1	FMN-binding protein MioC	-
K6J55_RS01845 (CHBNII4_03430)	372689..372907	-	219	WP_005650820.1	cell division protein ZapB	-
K6J55_RS01850 (CHBNII4_03440)	373069..374070	+	1002	WP_221257440.1	class II fructose-bisphosphatase	-
K6J55_RS01855 (CHBNII4_03450)	374275..374583	+	309	WP_048942802.1	helix-turn-helix transcriptional regulator	-
K6J55_RS01860 (CHBNII4_03460)	374571..374891	+	321	WP_011272158.1	HipA N-terminal domain-containing protein	Antitoxin
K6J55_RS01865 (CHBNII4_03470)	374888..375919	+	1032	WP_048942801.1	HipA domain-containing protein	Toxin
K6J55_RS01870 (CHBNII4_03480)	376003..377661	-	1659	WP_048942800.1	ABC transporter ATP-binding protein	-
K6J55_RS01875 (CHBNII4_03490)	377654..379399	-	1746	WP_048942799.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39826.37 Da
• Isoelectric Point: 6.6934

>T32106 WP_048942801.1 NZ_AP018767:374888-375919 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
ETFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T32106 NZ_AP018767:374888-375919 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTACATTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCACATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCGCCAATTTATGATTTTGTGTCGGTGTCGCCCTACCCT
GAAACATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGAGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATACCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCACAACCGCAT
ATTGATTGCGTACTGAAAACTTATCGCAAGCGTTTAGCGTTACTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12437.12 Da
• Isoelectric Point: 5.9670

>AT32106 WP_011272158.1 NZ_AP018767:374571-374891 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT32106 NZ_AP018767:374571-374891 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCCCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: Q4QMQ1