32106

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 374571..375919 Replicon chromosome
Accession NZ_AP018767
Organism Haemophilus influenzae strain CHBN-II-4 isolate 13H33

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K6J55_RS01865 Protein ID WP_048942801.1
Coordinates 374888..375919 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q4QMQ1
Locus tag K6J55_RS01860 Protein ID WP_011272158.1
Coordinates 374571..374891 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J55_RS01815 (CHBNII4_03370) 369790..370068 + 279 WP_105886796.1 cell division protein FtsB -
K6J55_RS01820 (CHBNII4_03380) 370068..370745 + 678 WP_110431195.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K6J55_RS01825 (CHBNII4_03390) 370742..371218 + 477 WP_005658971.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K6J55_RS01830 (CHBNII4_03400) 371288..371455 - 168 WP_181145040.1 hypothetical protein -
K6J55_RS01835 (CHBNII4_03410) 371720..372154 - 435 WP_221257438.1 D-aminoacyl-tRNA deacylase -
K6J55_RS01840 (CHBNII4_03420) 372151..372591 - 441 WP_221257439.1 FMN-binding protein MioC -
K6J55_RS01845 (CHBNII4_03430) 372689..372907 - 219 WP_005650820.1 cell division protein ZapB -
K6J55_RS01850 (CHBNII4_03440) 373069..374070 + 1002 WP_221257440.1 class II fructose-bisphosphatase -
K6J55_RS01855 (CHBNII4_03450) 374275..374583 + 309 WP_048942802.1 helix-turn-helix transcriptional regulator -
K6J55_RS01860 (CHBNII4_03460) 374571..374891 + 321 WP_011272158.1 HipA N-terminal domain-containing protein Antitoxin
K6J55_RS01865 (CHBNII4_03470) 374888..375919 + 1032 WP_048942801.1 HipA domain-containing protein Toxin
K6J55_RS01870 (CHBNII4_03480) 376003..377661 - 1659 WP_048942800.1 ABC transporter ATP-binding protein -
K6J55_RS01875 (CHBNII4_03490) 377654..379399 - 1746 WP_048942799.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39826.37 Da        Isoelectric Point: 6.6934

>T32106 WP_048942801.1 NZ_AP018767:374888-375919 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
ETFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

>T32106 NZ_AP018767:374888-375919 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTACATTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCACATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCGCCAATTTATGATTTTGTGTCGGTGTCGCCCTACCCT
GAAACATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGAGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATACCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCACAACCGCAT
ATTGATTGCGTACTGAAAACTTATCGCAAGCGTTTAGCGTTACTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12437.12 Da        Isoelectric Point: 5.9670

>AT32106 WP_011272158.1 NZ_AP018767:374571-374891 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT32106 NZ_AP018767:374571-374891 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCCCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q4QMQ1

References