Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2051516..2052174 Replicon chromosome
Accession NZ_AP018756
Organism Metakosakonia sp. MRY16-398

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MRY16398_RS09800 Protein ID WP_125124251.1
Coordinates 2051516..2051869 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A348DBJ5
Locus tag MRY16398_RS09805 Protein ID WP_071196363.1
Coordinates 2051872..2052174 (+) Length 101 a.a.

Genomic Context

MRY16398_RS09800MRY16398_RS09805MRY16398_RS09810MRY16398_RS09825MRY16398_RS09830MRY16398_RS09785MRY16398_RS09790MRY16398_RS09795MRY16398_RS09815MRY16398_RS09835
Location: 2051516..2051869 (354 bp)
Type: Toxin
Protein ID: WP_125124251.1
Location: 2051872..2052174 (303 bp)
Type: Antitoxin
Protein ID: WP_071196363.1
Location: 2052251..2053201 (951 bp)
Type: Others
Protein ID: WP_041851855.1
Location: 2054080..2054997 (918 bp)
Type: Others
Protein ID: WP_041851853.1
Location: 2055099..2056049 (951 bp)
Type: Others
Protein ID: WP_041851852.1
Location: 2047970..2049424 (1455 bp)
Type: Others
Protein ID: WP_041851859.1
Location: 2049618..2050595 (978 bp)
Type: Others
Protein ID: WP_125124250.1
Location: 2050653..2051297 (645 bp)
Type: Others
Protein ID: WP_041851857.1
Location: 2053294..2053482 (189 bp)
Type: Others
Protein ID: WP_041851854.1
Location: 2056101..2056577 (477 bp)
Type: Others
Protein ID: WP_071196365.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MRY16398_RS097852047970..2049424-1455WP_041851859.1AMP nucleosidase-
MRY16398_RS097902049618..2050595-978WP_125124250.1oxidoreductase-
MRY16398_RS097952050653..2051297-645WP_041851857.1TetR family transcriptional regulator C-terminal domain-containing protein-
MRY16398_RS098002051516..2051869+354WP_125124251.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MRY16398_RS098052051872..2052174+303WP_071196363.1XRE family transcriptional regulatorAntitoxin
MRY16398_RS098102052251..2053201+951WP_041851855.1L,D-transpeptidase-
MRY16398_RS098152053294..2053482-189WP_041851854.1YjfB family protein-
MRY16398_RS098252054080..2054997+918WP_041851853.1nitrogen assimilation transcriptional regulator NAC-
MRY16398_RS098302055099..2056049+951WP_041851852.1HTH-type transcriptional regulator Cbl-
MRY16398_RS098352056101..2056577-477WP_071196365.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13585.60 Da        Isoelectric Point: 9.4816

>T32070 WP_125124251.1 NZ_AP018756:2051516-2051869 [Metakosakonia sp. MRY16-398]
VWEIKTTDRFDEWLIAQNDHTRASVLAALIVLRTKGPELPRPWADTIKGARYSNMKELRIQCRGEPIRPFFAFDPRRAAI
VLCAGSKAGNEKRFYAEMISRAEQEYANYLKKPEKEE

Download         Length: 354 bp

>T32070 NZ_AP018756:2051516-2051869 [Metakosakonia sp. MRY16-398]
GTGTGGGAAATTAAAACAACGGACAGGTTTGATGAGTGGTTAATCGCTCAAAATGATCACACGCGTGCGAGCGTTTTGGC
GGCGCTGATCGTGTTGCGAACGAAAGGCCCCGAATTGCCCAGACCCTGGGCCGACACGATAAAAGGGGCGCGCTACAGCA
ATATGAAGGAGCTGCGAATTCAGTGTCGTGGGGAGCCGATACGCCCTTTTTTCGCTTTTGATCCCAGACGGGCGGCTATT
GTGTTGTGCGCAGGAAGTAAAGCTGGAAATGAAAAACGTTTCTACGCCGAAATGATTTCGCGAGCTGAGCAGGAATATGC
AAACTATCTGAAAAAACCAGAGAAAGAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11067.80 Da        Isoelectric Point: 6.2312

>AT32070 WP_071196363.1 NZ_AP018756:2051872-2052174 [Metakosakonia sp. MRY16-398]
MGRTLEQLLADEKPEVVAQAESMATETLLNIHLAELREKVQKTQVEMAHALGIRQPTVAGMEKPGRDVKLSTLKRYVEAT
GGKLRLDIELPDGSHYAFVV

Download         Length: 303 bp

>AT32070 NZ_AP018756:2051872-2052174 [Metakosakonia sp. MRY16-398]
ATGGGCAGAACGCTGGAACAACTGCTTGCGGATGAAAAACCAGAGGTTGTGGCGCAGGCTGAGTCAATGGCGACTGAGAC
TCTCCTGAACATTCACCTGGCCGAACTGCGTGAGAAAGTGCAAAAAACGCAGGTGGAAATGGCGCATGCACTGGGGATAC
GGCAACCTACGGTGGCGGGAATGGAAAAACCGGGTCGCGATGTAAAACTGTCGACGCTTAAGCGCTACGTTGAAGCCACT
GGCGGTAAGCTTCGTCTTGATATCGAACTGCCTGATGGGTCGCATTACGCCTTCGTTGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A348DBJ5

References