Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1185259..1185860 Replicon chromosome
Accession NZ_AP018721
Organism Sulfuritortus calidifontis strain J1A

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag EL388_RS06240 Protein ID WP_126461180.1
Coordinates 1185259..1185540 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL388_RS06245 Protein ID WP_126461183.1
Coordinates 1185555..1185860 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL388_RS06220 1181430..1182029 - 600 WP_126461168.1 TetR/AcrR family transcriptional regulator -
EL388_RS06225 1182105..1182647 - 543 WP_126461171.1 thermonuclease family protein -
EL388_RS06230 1182676..1183077 + 402 WP_126461174.1 hypothetical protein -
EL388_RS06235 1183087..1185180 - 2094 WP_126461177.1 conjugal transfer protein TraG N-terminal domain-containing protein -
EL388_RS06240 1185259..1185540 + 282 WP_126461180.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL388_RS06245 1185555..1185860 + 306 WP_126461183.1 HigA family addiction module antidote protein Antitoxin
EL388_RS14040 1185899..1186018 + 120 WP_197721833.1 toxin-antitoxin system HicB family antitoxin -
EL388_RS06255 1186082..1186828 - 747 WP_197721834.1 TSUP family transporter -
EL388_RS06260 1186878..1187666 - 789 WP_126461189.1 enoyl-ACP reductase FabI -
EL388_RS06265 1187751..1189901 + 2151 WP_126461192.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10648.06 Da        Isoelectric Point: 5.0893

>T31987 WP_126461180.1 NZ_AP018721:1185259-1185540 [Sulfuritortus calidifontis]
MTIRSFQCADTQALFEGASPKRFRNIESVAQRKLQMLDDAVELKDLRSPPGNRLEALCGDRADQYSIRINDQWRVCFVWT
AAGPDCVEIVDYH

Download         Length: 282 bp

>T31987 NZ_AP018721:1185259-1185540 [Sulfuritortus calidifontis]
ATGACGATTCGCTCATTCCAGTGCGCCGACACCCAAGCACTTTTCGAAGGGGCAAGCCCAAAGCGGTTTCGGAACATCGA
AAGCGTCGCGCAACGCAAGCTGCAAATGCTGGACGATGCGGTGGAGTTGAAGGATTTGCGCTCACCCCCAGGCAACCGCC
TGGAAGCATTATGCGGGGATCGCGCTGACCAATACAGCATCCGCATCAATGACCAGTGGCGTGTGTGCTTCGTTTGGACG
GCGGCCGGCCCGGACTGCGTTGAAATCGTGGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11363.20 Da        Isoelectric Point: 10.4369

>AT31987 WP_126461183.1 NZ_AP018721:1185555-1185860 [Sulfuritortus calidifontis]
MATNKMRPIHPGEILREEFLVPLGMSANALALALHVPAPRINDIVRERRGVTPDTALRLARFFDTTAQFWLNLQTAFDLK
QVEREAGGKIAEEVRPMQRAA

Download         Length: 306 bp

>AT31987 NZ_AP018721:1185555-1185860 [Sulfuritortus calidifontis]
ATGGCTACCAACAAGATGCGCCCGATTCACCCCGGTGAAATCCTCCGGGAGGAATTCCTTGTTCCCCTAGGTATGAGCGC
CAACGCGTTGGCGCTGGCCCTGCATGTGCCGGCGCCGAGGATCAATGACATTGTGCGCGAGCGTCGAGGGGTGACACCGG
ACACGGCCTTGCGGCTGGCCCGCTTCTTCGACACGACCGCGCAATTCTGGCTCAACCTGCAGACCGCCTTCGACCTGAAA
CAGGTGGAAAGGGAAGCTGGCGGGAAGATTGCCGAGGAAGTACGCCCGATGCAAAGGGCTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References