Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1185259..1185860 Replicon chromosome
Accession NZ_AP018721
Organism Sulfuritortus calidifontis strain J1A

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag EL388_RS06240 Protein ID WP_126461180.1
Coordinates 1185259..1185540 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL388_RS06245 Protein ID WP_126461183.1
Coordinates 1185555..1185860 (+) Length 102 a.a.

Genomic Context

EL388_RS06230EL388_RS06240EL388_RS06245EL388_RS14040EL388_RS06265EL388_RS06220EL388_RS06225EL388_RS06235EL388_RS06255EL388_RS06260
Location: 1182676..1183077 (402 bp)
Type: Others
Protein ID: WP_126461174.1
Location: 1185259..1185540 (282 bp)
Type: Toxin
Protein ID: WP_126461180.1
Location: 1185555..1185860 (306 bp)
Type: Antitoxin
Protein ID: WP_126461183.1
Location: 1185899..1186018 (120 bp)
Type: Others
Protein ID: WP_197721833.1
Location: 1187751..1189901 (2151 bp)
Type: Others
Protein ID: WP_126461192.1
Location: 1181430..1182029 (600 bp)
Type: Others
Protein ID: WP_126461168.1
Location: 1182105..1182647 (543 bp)
Type: Others
Protein ID: WP_126461171.1
Location: 1183087..1185180 (2094 bp)
Type: Others
Protein ID: WP_126461177.1
Location: 1186082..1186828 (747 bp)
Type: Others
Protein ID: WP_197721834.1
Location: 1186878..1187666 (789 bp)
Type: Others
Protein ID: WP_126461189.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL388_RS062201181430..1182029-600WP_126461168.1TetR/AcrR family transcriptional regulator-
EL388_RS062251182105..1182647-543WP_126461171.1thermonuclease family protein-
EL388_RS062301182676..1183077+402WP_126461174.1hypothetical protein-
EL388_RS062351183087..1185180-2094WP_126461177.1conjugal transfer protein TraG N-terminal domain-containing protein-
EL388_RS062401185259..1185540+282WP_126461180.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EL388_RS062451185555..1185860+306WP_126461183.1HigA family addiction module antidote proteinAntitoxin
EL388_RS140401185899..1186018+120WP_197721833.1toxin-antitoxin system HicB family antitoxin-
EL388_RS062551186082..1186828-747WP_197721834.1TSUP family transporter-
EL388_RS062601186878..1187666-789WP_126461189.1enoyl-ACP reductase FabI-
EL388_RS062651187751..1189901+2151WP_126461192.1ABC transporter substrate-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10648.06 Da        Isoelectric Point: 5.0893

>T31987 WP_126461180.1 NZ_AP018721:1185259-1185540 [Sulfuritortus calidifontis]
MTIRSFQCADTQALFEGASPKRFRNIESVAQRKLQMLDDAVELKDLRSPPGNRLEALCGDRADQYSIRINDQWRVCFVWT
AAGPDCVEIVDYH

Download         Length: 282 bp

>T31987 NZ_AP018721:1185259-1185540 [Sulfuritortus calidifontis]
ATGACGATTCGCTCATTCCAGTGCGCCGACACCCAAGCACTTTTCGAAGGGGCAAGCCCAAAGCGGTTTCGGAACATCGA
AAGCGTCGCGCAACGCAAGCTGCAAATGCTGGACGATGCGGTGGAGTTGAAGGATTTGCGCTCACCCCCAGGCAACCGCC
TGGAAGCATTATGCGGGGATCGCGCTGACCAATACAGCATCCGCATCAATGACCAGTGGCGTGTGTGCTTCGTTTGGACG
GCGGCCGGCCCGGACTGCGTTGAAATCGTGGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11363.20 Da        Isoelectric Point: 10.4369

>AT31987 WP_126461183.1 NZ_AP018721:1185555-1185860 [Sulfuritortus calidifontis]
MATNKMRPIHPGEILREEFLVPLGMSANALALALHVPAPRINDIVRERRGVTPDTALRLARFFDTTAQFWLNLQTAFDLK
QVEREAGGKIAEEVRPMQRAA

Download         Length: 306 bp

>AT31987 NZ_AP018721:1185555-1185860 [Sulfuritortus calidifontis]
ATGGCTACCAACAAGATGCGCCCGATTCACCCCGGTGAAATCCTCCGGGAGGAATTCCTTGTTCCCCTAGGTATGAGCGC
CAACGCGTTGGCGCTGGCCCTGCATGTGCCGGCGCCGAGGATCAATGACATTGTGCGCGAGCGTCGAGGGGTGACACCGG
ACACGGCCTTGCGGCTGGCCCGCTTCTTCGACACGACCGCGCAATTCTGGCTCAACCTGCAGACCGCCTTCGACCTGAAA
CAGGTGGAAAGGGAAGCTGGCGGGAAGATTGCCGAGGAAGTACGCCCGATGCAAAGGGCTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References