31981

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 707884..708479 Replicon chromosome
Accession NZ_AP018718
Organism Sulfuricystis multivorans strain J5B

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag EL335_RS03525 Protein ID WP_126444272.1
Coordinates 708201..708479 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag EL335_RS03520 Protein ID WP_126444271.1
Coordinates 707884..708189 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL335_RS03495 704126..704980 + 855 WP_126444266.1 endonuclease/exonuclease/phosphatase family protein -
EL335_RS03500 705824..706816 + 993 WP_126444267.1 WYL domain-containing protein -
EL335_RS03505 706875..707078 + 204 WP_126444268.1 hypothetical protein -
EL335_RS03510 707129..707494 - 366 WP_126444269.1 hypothetical protein -
EL335_RS03515 707482..707805 - 324 WP_126444270.1 superinfection immunity protein -
EL335_RS03520 707884..708189 - 306 WP_126444271.1 HigA family addiction module antitoxin Antitoxin
EL335_RS03525 708201..708479 - 279 WP_126444272.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL335_RS03530 708510..710627 - 2118 WP_126444273.1 HIRAN domain-containing protein -
EL335_RS03540 711217..711468 + 252 WP_126444274.1 HypC/HybG/HupF family hydrogenase formation chaperone -
EL335_RS03545 711465..712598 + 1134 WP_126444275.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10805.47 Da        Isoelectric Point: 11.2851

>T31981 WP_126444272.1 NZ_AP018718:c708479-708201 [Sulfuricystis multivorans]
MIRSFACADTEALFHSRPVLRFRNIERVARRKLLQLNAATELASLRIPPGNQLEALRGDRKGQHSIRINDQWRICFVWRK
DGAHRVEIVDYH

Download         Length: 279 bp

>T31981 NZ_AP018718:c708479-708201 [Sulfuricystis multivorans]
ATGATCCGATCGTTCGCCTGTGCCGACACCGAGGCGCTTTTCCATAGCCGGCCCGTGCTGCGGTTCCGAAACATCGAACG
GGTCGCGCGGCGCAAGCTGCTGCAGCTCAATGCGGCGACCGAGCTCGCGAGCTTGCGCATCCCCCCGGGGAACCAACTCG
AAGCCTTGAGAGGGGACCGCAAGGGCCAACACAGCATCCGCATCAACGACCAATGGCGCATCTGTTTCGTCTGGCGCAAA
GACGGCGCGCATCGGGTCGAAATCGTGGACTATCACTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11487.39 Da        Isoelectric Point: 6.4827

>AT31981 WP_126444271.1 NZ_AP018718:c708189-707884 [Sulfuricystis multivorans]
MAKLLDEIHPGEILLEEFMKPLGITARQLAADIDVSPSRISEIVHGRRPITADTALRLGLYFGMDPRFWINLQAEYDMRI
AMRELHDQIAPRIRTLHAAPA

Download         Length: 306 bp

>AT31981 NZ_AP018718:c708189-707884 [Sulfuricystis multivorans]
ATGGCGAAACTGCTCGACGAAATCCATCCCGGAGAGATCCTGCTGGAAGAGTTCATGAAGCCATTGGGGATCACGGCGCG
GCAACTCGCGGCCGACATCGACGTCTCCCCGAGCCGCATCAGCGAGATCGTTCACGGCCGCCGACCCATCACGGCCGATA
CCGCCTTGCGTCTGGGGCTCTACTTTGGCATGGACCCCAGGTTCTGGATCAATCTGCAGGCGGAGTACGACATGCGCATC
GCGATGCGCGAGCTTCACGACCAGATCGCGCCCCGCATCCGCACATTGCATGCGGCCCCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References