Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 13871..14529 | Replicon | plasmid 1 |
Accession | NZ_AP018687 | ||
Organism | Vibrio rumoiensis strain FERM P-14531 |
Toxin (Protein)
Gene name | higB | Uniprot ID | D3VM97 |
Locus tag | VRUMOI_RS17860 | Protein ID | WP_013141682.1 |
Coordinates | 13871..14221 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0K2S392 |
Locus tag | VRUMOI_RS17865 | Protein ID | WP_071681528.1 |
Coordinates | 14227..14529 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
VRUMOI_RS17820 | 9920..10852 | - | 933 | WP_071681513.1 | hypothetical protein | - |
VRUMOI_RS17830 | 11436..11939 | - | 504 | WP_071681517.1 | DUF1643 domain-containing protein | - |
VRUMOI_RS17835 | 12036..12377 | + | 342 | WP_071681518.1 | hypothetical protein | - |
VRUMOI_RS17840 | 12392..12862 | - | 471 | WP_071681520.1 | hypothetical protein | - |
VRUMOI_RS17845 | 12855..13226 | - | 372 | WP_071681522.1 | hypothetical protein | - |
VRUMOI_RS17850 | 13237..13431 | - | 195 | WP_071681524.1 | hypothetical protein | - |
VRUMOI_RS17860 | 13871..14221 | + | 351 | WP_013141682.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
VRUMOI_RS17865 | 14227..14529 | + | 303 | WP_071681528.1 | XRE family transcriptional regulator | Antitoxin |
VRUMOI_RS17870 | 14558..14851 | - | 294 | WP_071681628.1 | chromosome segregation protein ParM | - |
VRUMOI_RS17875 | 14941..15213 | - | 273 | WP_013141679.1 | HU family DNA-binding protein | - |
VRUMOI_RS17880 | 15223..15648 | - | 426 | WP_089140464.1 | ATP-binding protein | - |
VRUMOI_RS17885 | 15717..16244 | - | 528 | WP_071681532.1 | thermonuclease family protein | - |
VRUMOI_RS19395 | 16260..16562 | - | 303 | WP_174208834.1 | hypothetical protein | - |
VRUMOI_RS17895 | 16474..17331 | - | 858 | WP_071681537.1 | hypothetical protein | - |
VRUMOI_RS17900 | 17318..17548 | - | 231 | WP_089140465.1 | hypothetical protein | - |
VRUMOI_RS17905 | 17548..18066 | - | 519 | WP_089140466.1 | nitrite reductase | - |
VRUMOI_RS17910 | 18063..18509 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
VRUMOI_RS17915 | 18519..19517 | - | 999 | WP_089140467.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | katA | 1..159324 | 159324 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13300.16 Da Isoelectric Point: 5.2421
>T31974 WP_013141682.1 NZ_AP018687:13871-14221 [Vibrio rumoiensis]
MWAIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPLRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWAIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPLRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T31974 NZ_AP018687:13871-14221 [Vibrio rumoiensis]
ATGTGGGCCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACTGATAGAGCCAACGTCCTTGC
TTCGATGATGGTACTTCGTGACAGAGGTCCTATGCTTTCGAGGCCATACGCTGACACTGTGAACGGTTCATCCTACAGCA
ACATGAAAGAGCTACGGGTTCAAAGCAAAGGAGATCCTCTCAGAGCGTTCTTTGCATTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGTGCCGGTAATAAGACTGGGGATGAGAAACGATTTTATGAAGTAATGATCCCAATTGCAGACCGTGAATTTGC
GGCGCACTTGGATAAATTAAAGAAGGAGTAA
ATGTGGGCCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACTGATAGAGCCAACGTCCTTGC
TTCGATGATGGTACTTCGTGACAGAGGTCCTATGCTTTCGAGGCCATACGCTGACACTGTGAACGGTTCATCCTACAGCA
ACATGAAAGAGCTACGGGTTCAAAGCAAAGGAGATCCTCTCAGAGCGTTCTTTGCATTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGTGCCGGTAATAAGACTGGGGATGAGAAACGATTTTATGAAGTAATGATCCCAATTGCAGACCGTGAATTTGC
GGCGCACTTGGATAAATTAAAGAAGGAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 10952.72 Da Isoelectric Point: 9.5936
>AT31974 WP_071681528.1 NZ_AP018687:14227-14529 [Vibrio rumoiensis]
MARTLDQMLATEKPDVVAKAQKAATEMLLNIHLAELRSRMKLTQGEIAASLGVKQPTVSDMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFSV
MARTLDQMLATEKPDVVAKAQKAATEMLLNIHLAELRSRMKLTQGEIAASLGVKQPTVSDMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFSV
Download Length: 303 bp
>AT31974 NZ_AP018687:14227-14529 [Vibrio rumoiensis]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGATGTTGTTGCCAAAGCACAGAAAGCGGCGACTGAAAT
GTTGCTGAACATCCACCTAGCAGAGCTTCGCTCTCGCATGAAACTCACCCAAGGTGAAATTGCTGCTTCTCTGGGGGTTA
AACAACCGACAGTCTCTGATATGGAGAAACCTGGACGAGATCTAAAACTTTCGTCCATTAAGCGCTACGTTGAGGCATCC
GGCGGTAAGCTGCGACTCGATGTGGAACTGCCGGACGGCACCCACTACGGTTTTTCTGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGATGTTGTTGCCAAAGCACAGAAAGCGGCGACTGAAAT
GTTGCTGAACATCCACCTAGCAGAGCTTCGCTCTCGCATGAAACTCACCCAAGGTGAAATTGCTGCTTCTCTGGGGGTTA
AACAACCGACAGTCTCTGATATGGAGAAACCTGGACGAGATCTAAAACTTTCGTCCATTAAGCGCTACGTTGAGGCATCC
GGCGGTAAGCTGCGACTCGATGTGGAACTGCCGGACGGCACCCACTACGGTTTTTCTGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A501XS03 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0K2S392 |