Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 13871..14529 Replicon plasmid 1
Accession NZ_AP018687
Organism Vibrio rumoiensis strain FERM P-14531

Toxin (Protein)


Gene name higB Uniprot ID D3VM97
Locus tag VRUMOI_RS17860 Protein ID WP_013141682.1
Coordinates 13871..14221 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0K2S392
Locus tag VRUMOI_RS17865 Protein ID WP_071681528.1
Coordinates 14227..14529 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VRUMOI_RS17820 9920..10852 - 933 WP_071681513.1 hypothetical protein -
VRUMOI_RS17830 11436..11939 - 504 WP_071681517.1 DUF1643 domain-containing protein -
VRUMOI_RS17835 12036..12377 + 342 WP_071681518.1 hypothetical protein -
VRUMOI_RS17840 12392..12862 - 471 WP_071681520.1 hypothetical protein -
VRUMOI_RS17845 12855..13226 - 372 WP_071681522.1 hypothetical protein -
VRUMOI_RS17850 13237..13431 - 195 WP_071681524.1 hypothetical protein -
VRUMOI_RS17860 13871..14221 + 351 WP_013141682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VRUMOI_RS17865 14227..14529 + 303 WP_071681528.1 XRE family transcriptional regulator Antitoxin
VRUMOI_RS17870 14558..14851 - 294 WP_071681628.1 chromosome segregation protein ParM -
VRUMOI_RS17875 14941..15213 - 273 WP_013141679.1 HU family DNA-binding protein -
VRUMOI_RS17880 15223..15648 - 426 WP_089140464.1 ATP-binding protein -
VRUMOI_RS17885 15717..16244 - 528 WP_071681532.1 thermonuclease family protein -
VRUMOI_RS19395 16260..16562 - 303 WP_174208834.1 hypothetical protein -
VRUMOI_RS17895 16474..17331 - 858 WP_071681537.1 hypothetical protein -
VRUMOI_RS17900 17318..17548 - 231 WP_089140465.1 hypothetical protein -
VRUMOI_RS17905 17548..18066 - 519 WP_089140466.1 nitrite reductase -
VRUMOI_RS17910 18063..18509 - 447 WP_000919345.1 Fe3+-siderophore ABC transporter permease -
VRUMOI_RS17915 18519..19517 - 999 WP_089140467.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..159324 159324


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(17-89)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13300.16 Da        Isoelectric Point: 5.2421

>T31974 WP_013141682.1 NZ_AP018687:13871-14221 [Vibrio rumoiensis]
MWAIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPLRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE

Download         Length: 351 bp

>T31974 NZ_AP018687:13871-14221 [Vibrio rumoiensis]
ATGTGGGCCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACTGATAGAGCCAACGTCCTTGC
TTCGATGATGGTACTTCGTGACAGAGGTCCTATGCTTTCGAGGCCATACGCTGACACTGTGAACGGTTCATCCTACAGCA
ACATGAAAGAGCTACGGGTTCAAAGCAAAGGAGATCCTCTCAGAGCGTTCTTTGCATTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGTGCCGGTAATAAGACTGGGGATGAGAAACGATTTTATGAAGTAATGATCCCAATTGCAGACCGTGAATTTGC
GGCGCACTTGGATAAATTAAAGAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10952.72 Da        Isoelectric Point: 9.5936

>AT31974 WP_071681528.1 NZ_AP018687:14227-14529 [Vibrio rumoiensis]
MARTLDQMLATEKPDVVAKAQKAATEMLLNIHLAELRSRMKLTQGEIAASLGVKQPTVSDMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFSV

Download         Length: 303 bp

>AT31974 NZ_AP018687:14227-14529 [Vibrio rumoiensis]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGATGTTGTTGCCAAAGCACAGAAAGCGGCGACTGAAAT
GTTGCTGAACATCCACCTAGCAGAGCTTCGCTCTCGCATGAAACTCACCCAAGGTGAAATTGCTGCTTCTCTGGGGGTTA
AACAACCGACAGTCTCTGATATGGAGAAACCTGGACGAGATCTAAAACTTTCGTCCATTAAGCGCTACGTTGAGGCATCC
GGCGGTAAGCTGCGACTCGATGTGGAACTGCCGGACGGCACCCACTACGGTTTTTCTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A501XS03

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2S392

References