Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1552557..1553172 | Replicon | chromosome |
| Accession | NZ_AP018677 | ||
| Organism | Vibrio cholerae strain V060002 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | V060002_RS07690 | Protein ID | WP_001162670.1 |
| Coordinates | 1552885..1553172 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | V060002_RS07685 | Protein ID | WP_001232701.1 |
| Coordinates | 1552557..1552874 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V060002_RS07635 | 1547966..1548481 | - | 516 | WP_001201528.1 | lipocalin family protein | - |
| V060002_RS07640 | 1548618..1549094 | - | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
| V060002_RS07645 | 1549122..1549232 | - | 111 | WP_071917832.1 | DUF3265 domain-containing protein | - |
| V060002_RS07650 | 1549229..1550158 | - | 930 | WP_000335802.1 | hypothetical protein | - |
| V060002_RS07655 | 1550278..1550724 | - | 447 | WP_000128977.1 | hypothetical protein | - |
| V060002_RS07660 | 1550877..1551881 | - | 1005 | WP_000964925.1 | LD-carboxypeptidase | - |
| V060002_RS07665 | 1552094..1552132 | - | 39 | WP_106019119.1 | hypothetical protein | - |
| V060002_RS07670 | 1552148..1552273 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| V060002_RS19510 | 1552450..1552560 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| V060002_RS07685 | 1552557..1552874 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| V060002_RS07690 | 1552885..1553172 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| V060002_RS07695 | 1553439..1553619 | - | 181 | Protein_1418 | DUF645 family protein | - |
| V060002_RS07700 | 1554044..1554277 | - | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| V060002_RS07705 | 1554680..1554898 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| V060002_RS07710 | 1555208..1555861 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| V060002_RS07715 | 1555918..1556427 | - | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| V060002_RS07720 | 1556669..1556911 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| V060002_RS07725 | 1556930..1557247 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| V060002_RS19515 | 1557441..1557536 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 1516275..1622843 | 106568 | |
| - | inside | Integron | - | - | 1511738..1563819 | 52081 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T31959 WP_001162670.1 NZ_AP018677:c1553172-1552885 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T31959 NZ_AP018677:c1553172-1552885 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT31959 WP_001232701.1 NZ_AP018677:c1552874-1552557 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT31959 NZ_AP018677:c1552874-1552557 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|