Detailed information of TA system TA031916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 330996..331515
• Replicon: chromosome
• Accession: NZ_AP018587
• Organism: Staphylococcus caprae strain JMUB898

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JMUB898_RS01415
• Protein ID: WP_037541722.1
• Coordinates: 330996..331265 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JMUB898_RS01420
• Protein ID: WP_037541721.1
• Coordinates: 331258..331515 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMUB898_RS01395	327907..328665	+	759	WP_002444608.1	esterase family protein	-
JMUB898_RS01400	328747..329058	-	312	WP_002444606.1	SdpI family protein	-
JMUB898_RS01405	329296..330435	+	1140	WP_095323335.1	CapA family protein	-
JMUB898_RS01410	330486..330851	-	366	WP_037541723.1	DUF4870 domain-containing protein	-
JMUB898_RS01415	330996..331265	-	270	WP_037541722.1	Txe/YoeB family addiction module toxin	Toxin
JMUB898_RS01420	331258..331515	-	258	WP_037541721.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JMUB898_RS01425	331705..332562	+	858	WP_002444596.1	ABC transporter substrate-binding protein	-
JMUB898_RS01430	332676..334316	-	1641	WP_126501885.1	alpha-keto acid decarboxylase family protein	-
JMUB898_RS01435	334488..334934	+	447	WP_002444594.1	MarR family winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10552.23 Da
• Isoelectric Point: 10.0266

>T31916 WP_037541722.1 NZ_AP018587:c331265-330996 [Staphylococcus caprae]
MSKLNVTFTTQAFKDYQFWQQHNLGNFKKINTLLKSIARDGCIEGIGKPEALKVNYEGYYSRRITIEHRLVYKIKNDSIF
IVSCRFHYL

Nucleotide

• Length: 270 bp

>T31916 NZ_AP018587:c331265-330996 [Staphylococcus caprae]
ATGAGTAAACTTAATGTGACTTTTACAACTCAAGCATTTAAAGATTATCAATTTTGGCAACAACATAACTTAGGAAATTT
TAAAAAAATTAACACTTTACTTAAAAGTATCGCACGAGATGGTTGCATCGAGGGTATCGGGAAACCGGAAGCGCTAAAAG
TCAATTATGAAGGTTATTATAGTAGGAGAATCACGATTGAACATCGGTTAGTATACAAAATAAAGAATGATTCTATTTTT
ATAGTGTCTTGTAGATTTCATTACCTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9694.68 Da
• Isoelectric Point: 4.1677

>AT31916 WP_037541721.1 NZ_AP018587:c331515-331258 [Staphylococcus caprae]
MPSINYSNARQNFKELISKVNEDSVTYTITTKEDKNAVILAEKDYNAILETMYLQSNPANVSHLNKSIQELNQNDTITVE
IDDNE

Nucleotide

• Length: 258 bp

>AT31916 NZ_AP018587:c331515-331258 [Staphylococcus caprae]
ATGCCATCCATAAATTATTCCAATGCACGTCAAAATTTTAAAGAACTGATTTCTAAAGTAAACGAAGACAGTGTAACTTA
CACAATTACAACGAAAGAAGATAAGAATGCTGTCATTCTAGCTGAGAAAGATTACAATGCAATTCTAGAAACGATGTATC
TTCAGTCAAATCCGGCTAATGTGTCTCACCTGAACAAATCCATTCAAGAATTAAACCAAAACGATACGATTACAGTTGAG
ATTGATGATAATGAGTAA