Detailed information of TA system TA031911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 345491..346010
• Replicon: chromosome
• Accession: NZ_AP018586
• Organism: Staphylococcus caprae strain JMUB590

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EL289_RS01465
• Protein ID: WP_037541722.1
• Coordinates: 345491..345760 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EL289_RS01470
• Protein ID: WP_037541721.1
• Coordinates: 345753..346010 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL289_RS01445	342402..343160	+	759	WP_002444608.1	esterase family protein	-
EL289_RS01450	343242..343553	-	312	WP_002444606.1	SdpI family protein	-
EL289_RS01455	343791..344930	+	1140	WP_095323335.1	CapA family protein	-
EL289_RS01460	344981..345346	-	366	WP_037541723.1	DUF4870 domain-containing protein	-
EL289_RS01465	345491..345760	-	270	WP_037541722.1	Txe/YoeB family addiction module toxin	Toxin
EL289_RS01470	345753..346010	-	258	WP_037541721.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EL289_RS01475	346200..347057	+	858	WP_002444596.1	ABC transporter substrate-binding protein	-
EL289_RS01480	347171..348811	-	1641	WP_126501885.1	alpha-keto acid decarboxylase family protein	-
EL289_RS01485	348983..349429	+	447	WP_002444594.1	MarR family winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10552.23 Da
• Isoelectric Point: 10.0266

>T31911 WP_037541722.1 NZ_AP018586:c345760-345491 [Staphylococcus caprae]
MSKLNVTFTTQAFKDYQFWQQHNLGNFKKINTLLKSIARDGCIEGIGKPEALKVNYEGYYSRRITIEHRLVYKIKNDSIF
IVSCRFHYL

Nucleotide

• Length: 270 bp

>T31911 NZ_AP018586:c345760-345491 [Staphylococcus caprae]
ATGAGTAAACTTAATGTGACTTTTACAACTCAAGCATTTAAAGATTATCAATTTTGGCAACAACATAACTTAGGAAATTT
TAAAAAAATTAACACTTTACTTAAAAGTATCGCACGAGATGGTTGCATCGAGGGTATCGGGAAACCGGAAGCGCTAAAAG
TCAATTATGAAGGTTATTATAGTAGGAGAATCACGATTGAACATCGGTTAGTATACAAAATAAAGAATGATTCTATTTTT
ATAGTGTCTTGTAGATTTCATTACCTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9694.68 Da
• Isoelectric Point: 4.1677

>AT31911 WP_037541721.1 NZ_AP018586:c346010-345753 [Staphylococcus caprae]
MPSINYSNARQNFKELISKVNEDSVTYTITTKEDKNAVILAEKDYNAILETMYLQSNPANVSHLNKSIQELNQNDTITVE
IDDNE

Nucleotide

• Length: 258 bp

>AT31911 NZ_AP018586:c346010-345753 [Staphylococcus caprae]
ATGCCATCCATAAATTATTCCAATGCACGTCAAAATTTTAAAGAACTGATTTCTAAAGTAAACGAAGACAGTGTAACTTA
CACAATTACAACGAAAGAAGATAAGAATGCTGTCATTCTAGCTGAGAAAGATTACAATGCAATTCTAGAAACGATGTATC
TTCAGTCAAATCCGGCTAATGTGTCTCACCTGAACAAATCCATTCAAGAATTAAACCAAAACGATACGATTACAGTTGAG
ATTGATGATAATGAGTAA