31902

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2411645..2412162 Replicon chromosome
Accession NZ_AP018562
Organism Staphylococcus argenteus strain 58113

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7U7PWL3
Locus tag SA58113_RS11950 Protein ID WP_031787172.1
Coordinates 2411645..2411911 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7PWU0
Locus tag SA58113_RS11955 Protein ID WP_031787173.1
Coordinates 2411911..2412162 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA58113_RS11925 2407075..2407611 - 537 WP_031787169.1 GNAT family N-acetyltransferase -
SA58113_RS11930 2407844..2408668 - 825 WP_126495171.1 formate/nitrite transporter family protein -
SA58113_RS11935 2408885..2409070 - 186 WP_000230291.1 hypothetical protein -
SA58113_RS11940 2409154..2409621 - 468 WP_031787170.1 SRPBCC domain-containing protein -
SA58113_RS11945 2409804..2411348 - 1545 WP_031787171.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SA58113_RS11950 2411645..2411911 - 267 WP_031787172.1 Txe/YoeB family addiction module toxin Toxin
SA58113_RS11955 2411911..2412162 - 252 WP_031787173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SA58113_RS11960 2412434..2413033 - 600 WP_000162802.1 DsbA family protein -
SA58113_RS11965 2413053..2413415 - 363 WP_031787174.1 DUF4467 domain-containing protein -
SA58113_RS11970 2413669..2414919 + 1251 WP_031787175.1 aminoacyltransferase -
SA58113_RS11975 2415014..2415745 - 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
SA58113_RS11980 2415742..2416461 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10511.99 Da        Isoelectric Point: 9.7791

>T31902 WP_031787172.1 NZ_AP018562:c2411911-2411645 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLFGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

>T31902 NZ_AP018562:c2411911-2411645 [Staphylococcus argenteus]
ATGGCTAGGTTAAACATTACGTTCTCGCCTCAGGCATTTGAAGATTATGAGTATTTTCAGCAGAACGATAAAAAAATGGT
AAAGAAGATTAATGAGTTACTTAAAAGCATTGATAGAAATGGTGCATTGCAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATTTATTTGGCTATTATAGTAGACGTATCAATCACGAACATAGGTTGGTTTATACAGTTGACGATAATCACATAAAA
ATAGCATCCTGTAGATACCATTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9395.56 Da        Isoelectric Point: 4.3558

>AT31902 WP_031787173.1 NZ_AP018562:c2412162-2411911 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSIIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp

>AT31902 NZ_AP018562:c2412162-2411911 [Staphylococcus argenteus]
ATGATTGTAAAAAACTATTCTTACGCTAGACAGAATTTAAAGACGCTTATGACAAAGGTAAATGACGATAGTGATGTGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATTATGTCAGAAGCAGATTATAATTCTATAATTGAAACCCTTTACC
TTCAACAGAATCCAAATAATGCTGAACACTTAGCCCAATCAATTGCTGACTTAGAACGAGGCAAAATGGTAACGAAAGAA
ATAGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PWL3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7PWU0

References