Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 107060..107716 Replicon chromosome
Accession NZ_AP018560
Organism Aerosticca soli strain Dysh456

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ALSL_RS00500 Protein ID WP_126539930.1
Coordinates 107396..107716 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ALSL_RS00495 Protein ID WP_126535634.1
Coordinates 107060..107359 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALSL_RS00480 103513..105495 - 1983 WP_126535628.1 UvrD-helicase domain-containing protein -
ALSL_RS00485 105632..106285 + 654 WP_126535630.1 thymidine kinase -
ALSL_RS00490 106288..107049 + 762 WP_126535632.1 hypothetical protein -
ALSL_RS00495 107060..107359 - 300 WP_126535634.1 HigA family addiction module antidote protein Antitoxin
ALSL_RS00500 107396..107716 - 321 WP_126539930.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ALSL_RS00505 107731..108558 - 828 WP_126535636.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
ALSL_RS00510 108642..110048 - 1407 WP_126535638.1 NADP-dependent phosphogluconate dehydrogenase -
ALSL_RS00515 110125..110622 - 498 WP_126535640.1 hypothetical protein -
ALSL_RS00520 110619..111968 - 1350 WP_126539932.1 Gldg family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(36-106)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-94)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12438.19 Da        Isoelectric Point: 10.2305

>T31890 WP_126539930.1 NZ_AP018560:c107716-107396 [Aerosticca soli]
MTLVVNNDKRYDTSVIRTFRSADTEALFNGRRVRRWASIETVAMRKLAMLNRAGRLDDLRIPPANRLEALKGDLAGHYSI
RINDQFRVCFRWHRGDAYDVEIVDYH

Download         Length: 321 bp

>T31890 NZ_AP018560:c107716-107396 [Aerosticca soli]
ATGACGCTTGTCGTTAATAACGACAAACGTTATGATACGAGCGTGATCCGGACCTTTCGCAGCGCCGACACGGAAGCCCT
GTTCAACGGCAGGCGCGTCCGCCGCTGGGCCAGCATCGAAACCGTTGCCATGCGCAAACTCGCCATGCTCAACCGTGCCG
GCCGCCTGGACGATCTGCGCATACCGCCCGCCAACCGCCTGGAAGCCTTGAAGGGCGACCTGGCTGGCCACTACAGCATC
CGCATCAATGACCAGTTCCGCGTGTGTTTCCGCTGGCACCGAGGCGATGCCTATGACGTGGAAATCGTCGATTACCACTA
A

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11192.95 Da        Isoelectric Point: 9.6548

>AT31890 WP_126535634.1 NZ_AP018560:c107359-107060 [Aerosticca soli]
MRTVPYPHPGEILREEFLVPMGISQYRLAKAIDIPATRVGEIIAGRRGITADTGLRLARFFGTSEDFWIGLQADYDLALT
KDRIAQTLDAIKPWRRHAV

Download         Length: 300 bp

>AT31890 NZ_AP018560:c107359-107060 [Aerosticca soli]
ATGCGTACCGTTCCCTATCCGCACCCGGGTGAGATCCTGCGCGAGGAATTCCTCGTGCCGATGGGCATCAGCCAGTATCG
CTTGGCCAAGGCCATCGACATTCCCGCCACGCGCGTCGGCGAGATCATCGCCGGCCGGCGCGGCATCACCGCCGACACTG
GCCTACGGTTGGCACGCTTTTTCGGTACCAGCGAGGATTTCTGGATCGGGCTGCAGGCCGATTACGACCTCGCCCTGACC
AAGGACCGTATCGCCCAGACGCTTGACGCCATCAAGCCCTGGCGTCGGCACGCCGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References