Detailed information of TA system TA031860

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-ratA/Fst(toxin)
• Location: 3279..3520
• Replicon: plasmid pKUB3006-1
• Accession: NZ_AP018539
• Organism: Enterococcus faecalis strain KUB3006

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: EL240_RS14685
• Protein ID: WP_002360667.1
• Coordinates: 3279..3389 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	3429..3520 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL240_RS14655	76..696	+	621	WP_161971471.1	recombinase family protein	-
EL240_RS14660	713..997	+	285	WP_002394798.1	hypothetical protein	-
EL240_RS14665	999..1232	+	234	WP_002394799.1	hypothetical protein	-
EL240_RS14670	1392..1646	-	255	WP_002394800.1	hypothetical protein	-
EL240_RS14675	1763..2431	-	669	WP_002403283.1	CPBP family intramembrane metalloprotease	-
EL240_RS14680	2467..2784	-	318	WP_002394802.1	heavy metal-binding domain-containing protein	-
EL240_RS14685	3279..3389	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	3429..3520	-	92	NuclAT_0	-	Antitoxin
-	3429..3520	-	92	NuclAT_0	-	Antitoxin
-	3429..3520	-	92	NuclAT_0	-	Antitoxin
-	3429..3520	-	92	NuclAT_0	-	Antitoxin
EL240_RS14690	3629..3928	+	300	WP_126300999.1	type III secretion system protein PrgN	-
EL240_RS14695	4713..5255	-	543	WP_086321354.1	hypothetical protein	-
EL240_RS14700	5265..6116	-	852	WP_002362419.1	ParA family protein	-
EL240_RS14705	6779..7795	+	1017	WP_033593833.1	replication initiator protein A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	erm(B) / aph(3')-III / dfrG / ant(6)-Ia / lsa(E) / lnu(B) / aac(6')-aph(2'')	prgB/asc10	1..106370	106370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T31860 WP_002360667.1 NZ_AP018539:3279-3389 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T31860 NZ_AP018539:3279-3389 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin

Nucleotide

• Length: 92 bp

>AT31860 NZ_AP018539:c3520-3429 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT

Structures

Antitoxin