Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2775051..2775388 Replicon chromosome
Accession NZ_AP018538
Organism Enterococcus faecalis strain KUB3006

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag EL240_RS14050 Protein ID WP_002381035.1
Coordinates 2775051..2775194 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2775126..2775388 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL240_RS14025 2770767..2771399 - 633 WP_002358972.1 RloB family protein -
EL240_RS14030 2771408..2772703 - 1296 WP_002371641.1 AAA family ATPase -
EL240_RS14045 2773165..2774781 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -
EL240_RS14050 2775051..2775194 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 2775126..2775388 - 263 - - Antitoxin
EL240_RS14055 2775389..2778388 - 3000 WP_033786695.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T31853 WP_002381035.1 NZ_AP018538:2775051-2775194 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T31853 NZ_AP018538:2775051-2775194 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 263 bp

>AT31853 NZ_AP018538:c2775388-2775126 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References