Detailed information of TA system TA031828

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4539738..4539959
• Replicon: chromosome
• Accession: NZ_AP018488
• Organism: Escherichia coli O157:H7 strain PV15-279

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ECpv15279_RS23600
• Protein ID: WP_001295224.1
• Coordinates: 4539738..4539845 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4539894..4539959 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECpv15279_RS23575	4534991..4535743	-	753	WP_000279530.1	cellulose biosynthesis protein BcsQ	-
ECpv15279_RS23580	4535755..4535943	-	189	WP_001063316.1	YhjR family protein	-
ECpv15279_RS23585	4536216..4537787	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
ECpv15279_RS23590	4537784..4537975	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ECpv15279_RS23595	4537972..4539651	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
ECpv15279_RS23600	4539738..4539845	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4539894..4539959	+	66	NuclAT_16	-	Antitoxin
-	4539894..4539959	+	66	NuclAT_16	-	Antitoxin
-	4539894..4539959	+	66	NuclAT_16	-	Antitoxin
-	4539894..4539959	+	66	NuclAT_16	-	Antitoxin
-	4539894..4539959	+	66	NuclAT_21	-	Antitoxin
-	4539894..4539959	+	66	NuclAT_21	-	Antitoxin
-	4539894..4539959	+	66	NuclAT_21	-	Antitoxin
-	4539894..4539959	+	66	NuclAT_21	-	Antitoxin
ECpv15279_RS23605	4540321..4541592	+	1272	WP_001306601.1	amino acid permease	-
ECpv15279_RS23610	4541622..4542626	-	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ECpv15279_RS23615	4542623..4543606	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ECpv15279_RS23620	4543617..4544519	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T31828 WP_001295224.1 NZ_AP018488:c4539845-4539738 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T31828 NZ_AP018488:c4539845-4539738 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT31828 NZ_AP018488:4539894-4539959 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin