Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1311084..1311648 Replicon chromosome
Accession NZ_AP018392
Organism Lacticaseibacillus paracasei strain IJH-SONE68

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag EL355_RS06990 Protein ID WP_016363448.1
Coordinates 1311346..1311648 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag EL355_RS06985 Protein ID WP_003570051.1
Coordinates 1311084..1311353 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL355_RS06955 1306089..1306976 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
EL355_RS06960 1307173..1308399 - 1227 WP_003570043.1 hypothetical protein -
EL355_RS06965 1308597..1309001 + 405 WP_003570045.1 MerR family transcriptional regulator -
EL355_RS06970 1308994..1309320 + 327 WP_003584272.1 YrdB family protein -
EL355_RS06975 1309383..1310012 + 630 WP_003570047.1 DUF2399 domain-containing protein -
EL355_RS06980 1310057..1310710 + 654 WP_003570049.1 GNAT family N-acetyltransferase -
EL355_RS06985 1311084..1311353 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL355_RS06990 1311346..1311648 + 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
EL355_RS06995 1312248..1312940 + 693 WP_003570055.1 hypothetical protein -
EL355_RS07000 1313176..1315353 + 2178 WP_003570057.1 RNA-binding transcriptional accessory protein -
EL355_RS07005 1315778..1316341 - 564 WP_126353112.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T31775 WP_016363448.1 NZ_AP018392:1311346-1311648 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T31775 NZ_AP018392:1311346-1311648 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT31775 WP_003570051.1 NZ_AP018392:1311084-1311353 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT31775 NZ_AP018392:1311084-1311353 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References