Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 5253838..5254352 Replicon chromosome
Accession NZ_AP018365
Organism Streptomyces sp. SN-593

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag RVR_RS22360 Protein ID WP_202235544.1
Coordinates 5253838..5254098 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag RVR_RS22365 Protein ID WP_202235546.1
Coordinates 5254095..5254352 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVR_RS22335 5249687..5250130 + 444 WP_103886886.1 50S ribosomal protein L13 -
RVR_RS22340 5250170..5250685 + 516 WP_202235538.1 30S ribosomal protein S9 -
RVR_RS22345 5250880..5252238 + 1359 WP_202235540.1 phosphoglucosamine mutase -
RVR_RS22350 5252302..5253408 - 1107 WP_202238921.1 type I pantothenate kinase -
RVR_RS22355 5253467..5253835 + 369 WP_202235542.1 holo-ACP synthase -
RVR_RS22360 5253838..5254098 - 261 WP_202235544.1 Txe/YoeB family addiction module toxin Toxin
RVR_RS22365 5254095..5254352 - 258 WP_202235546.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
RVR_RS22370 5254464..5255903 + 1440 WP_202235548.1 NAD(P)H-hydrate dehydratase -
RVR_RS22375 5256523..5257680 + 1158 WP_202235550.1 alanine racemase -
RVR_RS22380 5257740..5259038 + 1299 WP_202235552.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10138.57 Da        Isoelectric Point: 8.2817

>T31766 WP_202235544.1 NZ_AP018365:c5254098-5253838 [Streptomyces sp. SN-593]
MKVVFDDAPWDDHVWWQVQDRKVLKRINALVEGIARNGNDGIGKPERLRHGFQGYWSRRITDEHRLVCKVVDDEIRIAAC
RYPYGC

Download         Length: 261 bp

>T31766 NZ_AP018365:c5254098-5253838 [Streptomyces sp. SN-593]
ATGAAGGTCGTCTTCGACGACGCGCCCTGGGACGACCACGTGTGGTGGCAGGTCCAGGACCGCAAGGTACTCAAGCGCAT
CAACGCTCTGGTCGAGGGCATCGCCCGCAACGGCAACGACGGCATCGGCAAGCCGGAGCGGCTGAGACACGGCTTCCAGG
GCTACTGGTCCCGCCGCATCACCGACGAGCACCGCCTCGTCTGCAAAGTGGTCGACGACGAGATCCGGATCGCGGCCTGC
CGTTACCCCTACGGGTGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9559.60 Da        Isoelectric Point: 4.4442

>AT31766 WP_202235546.1 NZ_AP018365:c5254352-5254095 [Streptomyces sp. SN-593]
MKTVTYSESRARYAEVLDSVNDDREEVVITRAGHDPVVIVSLDAYESLRETAYLLRSPADARRLLASIDRLEHGAGTPRE
LVEDE

Download         Length: 258 bp

>AT31766 NZ_AP018365:c5254352-5254095 [Streptomyces sp. SN-593]
ATGAAGACCGTGACGTACTCCGAGTCCCGCGCCCGGTACGCCGAGGTGCTGGACTCCGTGAACGACGACCGGGAAGAGGT
CGTCATCACCCGCGCCGGCCATGACCCGGTGGTGATCGTCTCTCTGGACGCGTACGAATCGCTCCGCGAGACCGCCTACC
TGCTCCGCAGCCCGGCCGACGCGCGCCGTCTCCTCGCGTCCATCGACCGGCTGGAGCACGGCGCCGGCACTCCCCGTGAA
CTGGTCGAGGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References