Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2518256..2518779 Replicon chromosome
Accession NZ_AP018349
Organism Staphylococcus aureus strain GN1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag D8S83_RS12915 Protein ID WP_042908766.1
Coordinates 2518256..2518522 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag D8S83_RS12920 Protein ID WP_020977565.1
Coordinates 2518522..2518779 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8S83_RS12895 2513466..2514653 - 1188 WP_000026189.1 MFS transporter -
D8S83_RS12900 2515049..2515825 - 777 WP_020977563.1 iron export ABC transporter permease subunit FetB -
D8S83_RS12905 2515818..2516480 - 663 WP_020977564.1 ATP-binding cassette domain-containing protein -
D8S83_RS12910 2516824..2517900 - 1077 WP_001076676.1 M42 family metallopeptidase -
D8S83_RS12915 2518256..2518522 - 267 WP_042908766.1 Txe/YoeB family addiction module toxin Toxin
D8S83_RS12920 2518522..2518779 - 258 WP_020977565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D8S83_RS12930 2519138..2519593 + 456 WP_000732085.1 YehR family lipoprotein -
D8S83_RS12935 2519768..2521345 - 1578 WP_000143488.1 FMN-binding glutamate synthase family protein -
D8S83_RS12940 2521540..2522289 + 750 WP_020977566.1 hypothetical protein -
D8S83_RS12945 2522513..2523706 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(28-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10638.34 Da        Isoelectric Point: 10.0798

>T31765 WP_042908766.1 NZ_AP018349:c2518522-2518256 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNDPCKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T31765 NZ_AP018349:c2518522-2518256 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTGTAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT31765 WP_020977565.1 NZ_AP018349:c2518779-2518522 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT31765 NZ_AP018349:c2518779-2518522 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTCAGAGAAAGAGAAAAAGATAATAGTGGTACTACAAATATAGACGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References