Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2461667..2462184 Replicon chromosome
Accession NZ_AP018349
Organism Staphylococcus aureus strain GN1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag D8S83_RS12610 Protein ID WP_000113263.1
Coordinates 2461667..2461933 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag D8S83_RS12615 Protein ID WP_000584499.1
Coordinates 2461933..2462184 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8S83_RS12585 2456871..2457407 - 537 WP_020977539.1 GNAT family N-acetyltransferase -
D8S83_RS12590 2457877..2458701 - 825 WP_000594640.1 formate/nitrite transporter family protein -
D8S83_RS12595 2458904..2459086 - 183 WP_000079140.1 hypothetical protein -
D8S83_RS12600 2459173..2459640 - 468 WP_020977540.1 SRPBCC domain-containing protein -
D8S83_RS12605 2459826..2461373 - 1548 WP_020977541.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
D8S83_RS12610 2461667..2461933 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
D8S83_RS12615 2461933..2462184 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D8S83_RS12620 2462357..2462449 - 93 Protein_2340 hypothetical protein -
D8S83_RS12625 2462456..2463055 - 600 WP_020977542.1 DsbA family protein -
D8S83_RS12630 2463074..2463436 - 363 WP_000819843.1 DUF4467 domain-containing protein -
D8S83_RS12635 2463691..2464941 + 1251 WP_064133576.1 FemA/FemB family glycyltransferase FmhA -
D8S83_RS12640 2465038..2465769 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
D8S83_RS12645 2465766..2466485 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T31762 WP_000113263.1 NZ_AP018349:c2461933-2461667 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T31762 NZ_AP018349:c2461933-2461667 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT31762 WP_000584499.1 NZ_AP018349:c2462184-2461933 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT31762 NZ_AP018349:c2462184-2461933 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACGCTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References