Detailed information of TA system TA031751

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1640274..1640853
• Replicon: chromosome
• Accession: NZ_AP018349
• Organism: Staphylococcus aureus strain GN1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: D8S83_RS08110
• Protein ID: WP_001025401.1
• Coordinates: 1640608..1640853 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1640274..1640639 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8S83_RS08070	1637018..1637575	-	558	WP_000645045.1	DUF2815 family protein	-
D8S83_RS08075	1637601..1638767	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
D8S83_RS08080	1638764..1639126	-	363	WP_000985972.1	hypothetical protein	-
D8S83_RS08085	1639141..1639464	-	324	WP_000174998.1	hypothetical protein	-
D8S83_RS08090	1639543..1639704	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
D8S83_RS08095	1639716..1639979	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
D8S83_RS08100	1640004..1640219	-	216	WP_001097552.1	hypothetical protein	-
D8S83_RS08105	1640274..1640639	+	366	WP_001128433.1	hypothetical protein	Antitoxin
D8S83_RS08110	1640608..1640853	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
D8S83_RS08115	1640903..1641121	-	219	WP_001001383.1	hypothetical protein	-
D8S83_RS08120	1641137..1641692	-	556	Protein_1526	phage antirepressor KilAC domain-containing protein	-
D8S83_RS08125	1641718..1641945	-	228	WP_001030311.1	hypothetical protein	-
D8S83_RS08130	1642117..1642731	+	615	WP_000801423.1	XRE family transcriptional regulator	-
D8S83_RS08135	1642747..1643667	+	921	WP_000348133.1	3'-5' exoribonuclease	-
D8S83_RS08140	1643763..1643945	+	183	WP_000705240.1	hypothetical protein	-
D8S83_RS08145	1644090..1644713	-	624	WP_001166482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1596957..1663657	66700

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T31751 WP_001025401.1 NZ_AP018349:c1640853-1640608 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T31751 NZ_AP018349:c1640853-1640608 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT31751 NZ_AP018349:1640274-1640639 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin