Detailed information of TA system TA031747

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 763195..763533
• Replicon: chromosome
• Accession: NZ_AP018349
• Organism: Staphylococcus aureus strain GN1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: D8S83_RS03685
• Protein ID: WP_011447039.1
• Coordinates: 763195..763371 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	763359..763533 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8S83_RS03665	758430..762215	+	3786	WP_020977044.1	bacteriophage minor structural protein	-
D8S83_RS03670	762205..762357	+	153	WP_001153681.1	hypothetical protein	-
D8S83_RS03675	762404..762691	+	288	WP_001040261.1	hypothetical protein	-
D8S83_RS03680	762749..763045	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
D8S83_RS03685	763195..763371	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	763359..763533	-	175	-	-	Antitoxin
D8S83_RS03695	763583..763837	+	255	WP_000611512.1	phage holin	-
D8S83_RS03700	763849..764604	+	756	WP_000861038.1	CHAP domain-containing protein	-
D8S83_RS03705	764795..765286	+	492	WP_000920037.1	staphylokinase	-
D8S83_RS03720	765936..766271	+	336	Protein_686	SH3 domain-containing protein	-
D8S83_RS03725	766366..766815	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
D8S83_RS03730	767500..767850	+	351	WP_000702263.1	complement inhibitor SCIN-A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	746371..792518	46147

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T31747 WP_011447039.1 NZ_AP018349:763195-763371 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T31747 NZ_AP018349:763195-763371 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT31747 NZ_AP018349:c763533-763359 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin