Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2328202..2328804 Replicon chromosome
Accession NZ_AP018112
Organism Burkholderia stabilis strain FERMP-21014

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BSFP_RS27580 Protein ID WP_197706765.1
Coordinates 2328202..2328489 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BSFP_RS27585 Protein ID WP_096474911.1
Coordinates 2328502..2328804 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSFP_RS27555 2323754..2325187 - 1434 WP_096474907.1 aldehyde dehydrogenase family protein -
BSFP_RS27560 2325217..2326857 - 1641 WP_096474908.1 acetolactate synthase large subunit -
BSFP_RS27570 2327187..2327525 + 339 WP_047901477.1 type II toxin-antitoxin system RelE/ParE family toxin -
BSFP_RS27575 2327529..2327828 + 300 WP_039344756.1 putative addiction module antidote protein -
BSFP_RS27580 2328202..2328489 + 288 WP_197706765.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSFP_RS27585 2328502..2328804 + 303 WP_096474911.1 HigA family addiction module antidote protein Antitoxin
BSFP_RS27590 2328838..2330124 - 1287 WP_096474912.1 DUF445 domain-containing protein -
BSFP_RS27595 2330336..2331556 - 1221 WP_096474913.1 FAD-dependent oxidoreductase -
BSFP_RS27600 2331546..2331872 - 327 WP_096474914.1 non-heme iron oxygenase ferredoxin subunit -
BSFP_RS27605 2331890..2332366 - 477 WP_014900133.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
BSFP_RS27610 2332381..2333652 - 1272 WP_096475667.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10998.56 Da        Isoelectric Point: 8.5478

>T31705 WP_197706765.1 NZ_AP018112:2328202-2328489 [Burkholderia stabilis]
MPVMIRSFRCKDTQSLFAGESPRRFRAIETVATRKLQMVAAAKELRDLRAPPGNRLEALQGDREGQHSIRINEQWRICFV
WSDDGPTQVEIVDYH

Download         Length: 288 bp

>T31705 NZ_AP018112:2328202-2328489 [Burkholderia stabilis]
ATGCCCGTAATGATCAGATCGTTCCGATGCAAGGATACCCAGTCGCTGTTTGCCGGAGAATCGCCCAGGCGCTTCCGCGC
GATCGAAACCGTTGCCACTCGGAAACTGCAAATGGTCGCCGCCGCGAAAGAACTGCGCGATTTGCGAGCGCCGCCCGGCA
ACCGGCTCGAAGCATTGCAAGGCGATCGGGAGGGCCAGCACAGCATCCGGATCAACGAACAATGGCGGATCTGTTTTGTT
TGGAGCGACGATGGGCCCACCCAGGTCGAGATCGTCGACTATCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11540.34 Da        Isoelectric Point: 9.6544

>AT31705 WP_096474911.1 NZ_AP018112:2328502-2328804 [Burkholderia stabilis]
MLRNGMRPIHPGEILREEFLVPLAMSVNALALALNVPATRLHEIVKERRGITADTAYRLARYFDTSPEFWLNLQAAYDLK
TLPTRSEIDRKVEPRERTHA

Download         Length: 303 bp

>AT31705 NZ_AP018112:2328502-2328804 [Burkholderia stabilis]
ATGCTCAGGAATGGAATGCGCCCGATTCATCCGGGCGAGATCCTGCGGGAAGAGTTTCTCGTGCCGCTGGCAATGAGCGT
CAACGCGCTGGCGCTCGCGTTGAACGTGCCGGCTACACGCTTGCACGAAATCGTCAAGGAACGGCGCGGCATCACGGCCG
ATACCGCTTACCGGCTCGCACGCTACTTCGACACGTCGCCGGAATTCTGGCTAAACCTGCAGGCCGCTTACGATCTCAAG
ACACTGCCGACGCGCAGCGAGATCGACCGCAAGGTCGAACCGCGCGAACGCACGCACGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References