Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2337111..2337694 Replicon chromosome
Accession NZ_AP018052
Organism Thiohalobacter thiocyanaticus strain FOKN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CFK21_RS10880 Protein ID WP_197703054.1
Coordinates 2337440..2337694 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CFK21_RS10875 Protein ID WP_096366676.1
Coordinates 2337111..2337443 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFK21_RS10850 2332252..2332677 + 426 WP_096366671.1 hypothetical protein -
CFK21_RS10855 2332695..2333546 + 852 WP_172844329.1 universal stress protein -
CFK21_RS10860 2333558..2334913 - 1356 WP_096366673.1 sigma-54 dependent transcriptional regulator -
CFK21_RS10865 2334910..2336382 - 1473 WP_172844295.1 sensor histidine kinase -
CFK21_RS10870 2336828..2337025 - 198 WP_096366675.1 type II toxin-antitoxin system VapB family antitoxin -
CFK21_RS10875 2337111..2337443 - 333 WP_096366676.1 helix-turn-helix domain-containing protein Antitoxin
CFK21_RS10880 2337440..2337694 - 255 WP_197703054.1 toxin higb- component of a toxin-antitoxin loci Toxin
CFK21_RS15410 2337953..2338207 - 255 WP_197702948.1 hypothetical protein -
CFK21_RS10885 2338566..2338772 + 207 WP_096366678.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CFK21_RS10890 2338769..2339146 + 378 WP_096366679.1 type II toxin-antitoxin system VapC family toxin -
CFK21_RS10895 2339546..2340451 - 906 WP_157745616.1 hypothetical protein -
CFK21_RS10900 2340553..2341647 - 1095 WP_096366681.1 DUF91 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9814.22 Da        Isoelectric Point: 10.2614

>T31692 WP_197703054.1 NZ_AP018052:c2337694-2337440 [Thiohalobacter thiocyanaticus]
MENPELGDVIPGTGGFRKLRWPDSRRGKGKRGGLRVIYYYLTDDGQIWFFALYDKDEAVDLSAEEKRLLKQAIQQELAAR
RRKR

Download         Length: 255 bp

>T31692 NZ_AP018052:c2337694-2337440 [Thiohalobacter thiocyanaticus]
CTGGAAAATCCGGAACTCGGTGATGTGATTCCCGGGACGGGCGGGTTCCGCAAGTTGCGCTGGCCGGATTCACGCCGGGG
CAAGGGAAAGCGGGGCGGTTTGCGGGTGATTTATTACTATCTCACCGACGATGGTCAGATCTGGTTCTTTGCGCTGTATG
ACAAGGACGAGGCGGTGGATTTAAGTGCCGAGGAAAAACGACTGCTTAAACAGGCGATTCAACAGGAGTTGGCCGCCAGG
AGGCGAAAGCGATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12654.55 Da        Isoelectric Point: 10.6370

>AT31692 WP_096366676.1 NZ_AP018052:c2337443-2337111 [Thiohalobacter thiocyanaticus]
MSRKRKLFDELMEGVDAMRSQREGKITLRTHEVEALPPLEIDPATIRETREKLHVSRAVFARHLRVSTRTLENWEQGRAR
PNAQAAALILMVRQYPDTLEKLHSLNNAAA

Download         Length: 333 bp

>AT31692 NZ_AP018052:c2337443-2337111 [Thiohalobacter thiocyanaticus]
ATGAGCAGGAAACGCAAGCTGTTTGATGAATTGATGGAAGGGGTGGATGCCATGCGCTCGCAGCGCGAGGGCAAGATCAC
GCTGCGTACCCACGAGGTTGAAGCATTGCCCCCGCTTGAGATCGATCCTGCCACCATTCGGGAGACGCGCGAAAAACTGC
ATGTGTCCCGTGCGGTGTTCGCCCGCCATCTGCGTGTGTCGACCCGAACCCTCGAAAATTGGGAACAAGGCCGCGCCAGA
CCCAATGCCCAGGCGGCGGCTCTGATCCTGATGGTTCGTCAGTACCCGGATACGCTGGAGAAGCTGCACTCACTCAACAA
TGCCGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References