Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2965386..2966034 Replicon chromosome
Accession NZ_AP018036
Organism Mycobacterium tuberculosis strain HN-506

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag CPZ04_RS14475 Protein ID WP_003899414.1
Coordinates 2965386..2965709 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CPZ04_RS14480 Protein ID WP_003899415.1
Coordinates 2965789..2966034 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ04_RS14445 2960709..2961707 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
CPZ04_RS14450 2961721..2962185 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
CPZ04_RS14455 2962173..2962424 + 252 WP_003908028.1 hypothetical protein -
CPZ04_RS14460 2962595..2964034 - 1440 WP_003901443.1 phage major capsid protein -
CPZ04_RS14465 2964042..2964575 - 534 WP_003899412.1 HK97 family phage prohead protease -
CPZ04_RS14470 2964728..2965219 - 492 WP_003900541.1 phage terminase small subunit P27 family -
CPZ04_RS14475 2965386..2965709 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
CPZ04_RS14480 2965789..2966034 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CPZ04_RS14485 2966031..2967458 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
CPZ04_RS14490 2967460..2967852 - 393 WP_003899417.1 DUF2742 domain-containing protein -
CPZ04_RS14495 2967849..2968109 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CPZ04_RS14500 2968126..2968488 - 363 WP_003900543.1 hypothetical protein -
CPZ04_RS14505 2968491..2969618 - 1128 WP_003899420.1 site-specific integrase -
CPZ04_RS14510 2969763..2969990 - 228 WP_003899421.1 hypothetical protein -
CPZ04_RS14515 2969987..2970376 - 390 WP_003899422.1 hypothetical protein -
CPZ04_RS14520 2970282..2970554 + 273 WP_003900544.1 hypothetical protein -
CPZ04_RS14525 2970653..2970886 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2960709..2969618 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T31676 WP_003899414.1 NZ_AP018036:c2965709-2965386 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T31676 NZ_AP018036:c2965709-2965386 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT31676 WP_003899415.1 NZ_AP018036:c2966034-2965789 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT31676 NZ_AP018036:c2966034-2965789 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References