31616

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2977133..2977781 Replicon chromosome
Accession NZ_AP018035
Organism Mycobacterium tuberculosis strain HN-321

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag CPZ12_RS14520 Protein ID WP_003899414.1
Coordinates 2977133..2977456 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CPZ12_RS14525 Protein ID WP_003899415.1
Coordinates 2977536..2977781 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ12_RS14490 2972456..2973454 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
CPZ12_RS14495 2973468..2973932 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
CPZ12_RS14500 2973920..2974171 + 252 WP_003908028.1 hypothetical protein -
CPZ12_RS14505 2974342..2975781 - 1440 WP_003901443.1 phage major capsid protein -
CPZ12_RS14510 2975789..2976322 - 534 WP_031666072.1 HK97 family phage prohead protease -
CPZ12_RS14515 2976475..2976966 - 492 WP_003900541.1 phage terminase small subunit P27 family -
CPZ12_RS14520 2977133..2977456 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
CPZ12_RS14525 2977536..2977781 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CPZ12_RS14530 2977778..2979205 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
CPZ12_RS14535 2979207..2979599 - 393 WP_003899417.1 DUF2742 domain-containing protein -
CPZ12_RS14540 2979596..2979856 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CPZ12_RS14545 2979873..2980235 - 363 WP_003900543.1 hypothetical protein -
CPZ12_RS14550 2980238..2981365 - 1128 WP_003899420.1 site-specific integrase -
CPZ12_RS14555 2981510..2981737 - 228 WP_003899421.1 hypothetical protein -
CPZ12_RS14560 2981734..2982123 - 390 WP_003899422.1 hypothetical protein -
CPZ12_RS14565 2982029..2982301 + 273 WP_003900544.1 hypothetical protein -
CPZ12_RS14570 2982400..2982633 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2972456..2981365 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-99)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T31616 WP_003899414.1 NZ_AP018035:c2977456-2977133 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T31616 NZ_AP018035:c2977456-2977133 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT31616 WP_003899415.1 NZ_AP018035:c2977781-2977536 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT31616 NZ_AP018035:c2977781-2977536 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References