Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2963596..2964244 Replicon chromosome
Accession NZ_AP018034
Organism Mycobacterium tuberculosis strain HN-205

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag CPZ09_RS14455 Protein ID WP_003899414.1
Coordinates 2963596..2963919 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CPZ09_RS14460 Protein ID WP_003899415.1
Coordinates 2963999..2964244 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ09_RS14425 2958919..2959917 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
CPZ09_RS14430 2959931..2960395 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
CPZ09_RS14435 2960383..2960634 + 252 WP_003908028.1 hypothetical protein -
CPZ09_RS14440 2960805..2962244 - 1440 WP_003901443.1 phage major capsid protein -
CPZ09_RS14445 2962252..2962785 - 534 WP_003899412.1 HK97 family phage prohead protease -
CPZ09_RS14450 2962938..2963429 - 492 WP_003900541.1 phage terminase small subunit P27 family -
CPZ09_RS14455 2963596..2963919 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
CPZ09_RS14460 2963999..2964244 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CPZ09_RS14465 2964241..2965668 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
CPZ09_RS14470 2965670..2966062 - 393 WP_003899417.1 DUF2742 domain-containing protein -
CPZ09_RS14475 2966059..2966319 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CPZ09_RS14480 2966336..2966698 - 363 WP_003900543.1 hypothetical protein -
CPZ09_RS14485 2966701..2967828 - 1128 WP_003899420.1 site-specific integrase -
CPZ09_RS14490 2967973..2968200 - 228 WP_003899421.1 hypothetical protein -
CPZ09_RS14495 2968197..2968586 - 390 WP_003899422.1 hypothetical protein -
CPZ09_RS14500 2968492..2968764 + 273 WP_003900544.1 hypothetical protein -
CPZ09_RS14505 2968863..2969096 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2958919..2967828 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T31556 WP_003899414.1 NZ_AP018034:c2963919-2963596 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T31556 NZ_AP018034:c2963919-2963596 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT31556 WP_003899415.1 NZ_AP018034:c2964244-2963999 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT31556 NZ_AP018034:c2964244-2963999 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References