Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 483832..484272 Replicon chromosome
Accession NZ_AP017977
Organism Neochlamydia sp. S13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TY21_RS11265 Protein ID WP_197725091.1
Coordinates 483832..483954 (+) Length 41 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag TY21_RS01865 Protein ID WP_042242378.1
Coordinates 483973..484272 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TY21_RS01835 479707..480039 - 333 WP_042240122.1 hypothetical protein -
TY21_RS01840 480039..480269 - 231 WP_042240118.1 hypothetical protein -
TY21_RS01845 480806..482056 + 1251 WP_174232785.1 group II intron reverse transcriptase/maturase -
TY21_RS01850 482413..483123 + 711 WP_052354581.1 sel1 repeat family protein -
TY21_RS01855 483438..483565 + 128 Protein_364 IS5/IS1182 family transposase -
TY21_RS11265 483832..483954 + 123 WP_197725091.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TY21_RS01865 483973..484272 + 300 WP_042242378.1 HigA family addiction module antidote protein Antitoxin
TY21_RS01870 484708..484899 + 192 WP_052354582.1 XRE family transcriptional regulator -
TY21_RS01875 484912..485769 - 858 WP_130589481.1 DUF1670 domain-containing protein -
TY21_RS01880 485766..486647 - 882 WP_130589482.1 DUF1670 domain-containing protein -
TY21_RS01885 486772..486975 + 204 WP_079979811.1 XRE family transcriptional regulator -
TY21_RS01890 487820..488143 + 324 WP_130589483.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(16-72)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4594.27 Da        Isoelectric Point: 7.0037

>T31446 WP_197725091.1 NZ_AP017977:483832-483954 [Neochlamydia sp. S13]
MGVLKGSFKGKYSIRINDQYPVVFTWGIRGPEQVEIIDDH

Download         Length: 123 bp

>T31446 NZ_AP017977:483832-483954 [Neochlamydia sp. S13]
CTGGGGGTTTTAAAAGGAAGCTTTAAAGGTAAGTACAGCATTCGTATTAATGATCAATATCCGGTTGTATTCACTTGGGG
TATCCGAGGGCCAGAGCAAGTTGAAATTATAGATGATCATTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11166.87 Da        Isoelectric Point: 9.6584

>AT31446 WP_042242378.1 NZ_AP017977:483973-484272 [Neochlamydia sp. S13]
VLPKNRSPIHPGEVLLEEFLKPLKLSQAQFASYLGGTWTQPKISEIINKKRGVTEAIALDFADALGTSPEFWLNLQNGYD
LWFARQNHQPIPRIPALKS

Download         Length: 300 bp

>AT31446 NZ_AP017977:483973-484272 [Neochlamydia sp. S13]
GTGCTTCCAAAAAATAGATCACCCATACATCCTGGAGAGGTGTTGTTAGAAGAATTTCTTAAACCTCTTAAGCTTTCGCA
AGCGCAATTTGCTAGTTACCTGGGAGGGACTTGGACTCAACCTAAAATTAGTGAAATCATCAACAAAAAACGAGGCGTAA
CGGAGGCAATAGCTCTAGATTTTGCGGATGCCTTAGGGACTTCGCCTGAATTTTGGCTTAATCTTCAAAATGGATATGAC
CTTTGGTTTGCAAGGCAAAACCATCAGCCGATTCCTCGAATACCTGCGCTAAAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References