Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1628276..1628788 Replicon chromosome
Accession NZ_AP017971
Organism Streptococcus pneumoniae strain KK0981

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag KK0981_RS08680 Protein ID WP_000924721.1
Coordinates 1628276..1628530 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag KK0981_RS08685 Protein ID WP_000388572.1
Coordinates 1628534..1628788 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK0981_RS08665 1625377..1625691 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
KK0981_RS08670 1625716..1626342 - 627 WP_000775037.1 guanylate kinase -
KK0981_RS08675 1626472..1628085 - 1614 WP_000404940.1 ribonuclease Y -
KK0981_RS08680 1628276..1628530 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
KK0981_RS08685 1628534..1628788 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KK0981_RS08695 1629026..1630123 - 1098 WP_000156337.1 nucleotidyltransferase -
KK0981_RS08700 1630133..1630879 - 747 WP_000605159.1 class I SAM-dependent methyltransferase -
KK0981_RS08705 1630982..1631335 - 354 WP_001003001.1 ribosome silencing factor -
KK0981_RS08710 1631348..1631848 - 501 WP_000844716.1 cysteine hydrolase -
KK0981_RS08715 1631849..1632442 - 594 WP_000121649.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
KK0981_RS08720 1632442..1633071 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
KK0981_RS08725 1633123..1633434 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T31442 WP_000924721.1 NZ_AP017971:c1628530-1628276 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T31442 NZ_AP017971:c1628530-1628276 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT31442 WP_000388572.1 NZ_AP017971:c1628788-1628534 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT31442 NZ_AP017971:c1628788-1628534 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGACGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References