Detailed information of TA system TA031431

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2135693..2135909
• Replicon: chromosome
• Accession: NZ_AP017922
• Organism: Staphylococcus aureus strain JP02758

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JP49775_RS10710
• Protein ID: WP_001802298.1
• Coordinates: 2135805..2135909 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2135693..2135748 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JP49775_RS10690	2131830..2132495	-	666	WP_001024099.1	SDR family oxidoreductase	-
JP49775_RS10695	2132647..2132967	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JP49775_RS10700	2132969..2133949	+	981	WP_029550399.1	CDF family zinc efflux transporter CzrB	-
JP49775_RS10705	2134215..2135306	+	1092	WP_029550400.1	hypothetical protein	-
-	2135693..2135748	+	56	-	-	Antitoxin
JP49775_RS10710	2135805..2135909	-	105	WP_001802298.1	hypothetical protein	Toxin
JP49775_RS10720	2136589..2136747	+	159	WP_001792784.1	hypothetical protein	-
JP49775_RS10725	2137183..2137275	+	93	WP_001794441.1	hypothetical protein	-
JP49775_RS10730	2137405..2138262	-	858	WP_029550401.1	Cof-type HAD-IIB family hydrolase	-
JP49775_RS10735	2138330..2139112	-	783	WP_029550402.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T31431 WP_001802298.1 NZ_AP017922:c2135909-2135805 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T31431 NZ_AP017922:c2135909-2135805 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT31431 NZ_AP017922:2135693-2135748 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin