Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2518093..2518616 Replicon chromosome
Accession NZ_AP017891
Organism Staphylococcus aureus strain GN3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CTB89_RS12905 Protein ID WP_042908766.1
Coordinates 2518093..2518359 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CTB89_RS12910 Protein ID WP_020977565.1
Coordinates 2518359..2518616 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTB89_RS12885 2513303..2514490 - 1188 WP_000026189.1 MFS transporter -
CTB89_RS12890 2514886..2515662 - 777 WP_020977563.1 iron export ABC transporter permease subunit FetB -
CTB89_RS12895 2515655..2516317 - 663 WP_020977564.1 ATP-binding cassette domain-containing protein -
CTB89_RS12900 2516661..2517737 - 1077 WP_001076676.1 M42 family metallopeptidase -
CTB89_RS12905 2518093..2518359 - 267 WP_042908766.1 Txe/YoeB family addiction module toxin Toxin
CTB89_RS12910 2518359..2518616 - 258 WP_020977565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CTB89_RS12920 2518975..2519430 + 456 WP_000732085.1 YehR family lipoprotein -
CTB89_RS12925 2519605..2521182 - 1578 WP_000143488.1 FMN-binding glutamate synthase family protein -
CTB89_RS12930 2521377..2522126 + 750 WP_020977566.1 hypothetical protein -
CTB89_RS12935 2522350..2523543 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(28-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10638.34 Da        Isoelectric Point: 10.0798

>T31351 WP_042908766.1 NZ_AP017891:c2518359-2518093 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNDPCKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T31351 NZ_AP017891:c2518359-2518093 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTGTAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT31351 WP_020977565.1 NZ_AP017891:c2518616-2518359 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT31351 NZ_AP017891:c2518616-2518359 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTCAGAGAAAGAGAAAAAGATAATAGTGGTACTACAAATATAGACGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References