Detailed information of TA system TA031337

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1638198..1638777
• Replicon: chromosome
• Accession: NZ_AP017891
• Organism: Staphylococcus aureus strain GN3

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CTB89_RS08095
• Protein ID: WP_001025401.1
• Coordinates: 1638532..1638777 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1638198..1638563 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTB89_RS08055	1634942..1635499	-	558	WP_000645045.1	DUF2815 family protein	-
CTB89_RS08060	1635525..1636691	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
CTB89_RS08065	1636688..1637050	-	363	WP_000985972.1	hypothetical protein	-
CTB89_RS08070	1637065..1637388	-	324	WP_000174998.1	hypothetical protein	-
CTB89_RS08075	1637467..1637628	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
CTB89_RS08080	1637640..1637903	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
CTB89_RS08085	1637928..1638143	-	216	WP_001097552.1	hypothetical protein	-
CTB89_RS08090	1638198..1638563	+	366	WP_001128433.1	hypothetical protein	Antitoxin
CTB89_RS08095	1638532..1638777	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CTB89_RS08100	1638827..1639045	-	219	WP_001001383.1	hypothetical protein	-
CTB89_RS08105	1639061..1639616	-	556	Protein_1523	phage antirepressor KilAC domain-containing protein	-
CTB89_RS08110	1639642..1639869	-	228	WP_001030311.1	hypothetical protein	-
CTB89_RS08115	1640041..1640655	+	615	WP_000801423.1	XRE family transcriptional regulator	-
CTB89_RS08120	1640671..1641591	+	921	WP_120173189.1	3'-5' exoribonuclease	-
CTB89_RS08125	1641687..1641869	+	183	WP_000705240.1	hypothetical protein	-
CTB89_RS08130	1642014..1642637	-	624	WP_001166482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1596802..1661581	64779

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T31337 WP_001025401.1 NZ_AP017891:c1638777-1638532 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T31337 NZ_AP017891:c1638777-1638532 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT31337 NZ_AP017891:1638198-1638563 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin