Detailed information of TA system TA031333

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 762806..763144
• Replicon: chromosome
• Accession: NZ_AP017891
• Organism: Staphylococcus aureus strain GN3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CTB89_RS03675
• Protein ID: WP_011447039.1
• Coordinates: 762806..762982 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	762970..763144 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTB89_RS03655	758041..761826	+	3786	WP_020977044.1	bacteriophage minor structural protein	-
CTB89_RS03660	761816..761968	+	153	WP_001153681.1	hypothetical protein	-
CTB89_RS03665	762015..762302	+	288	WP_001040261.1	hypothetical protein	-
CTB89_RS03670	762360..762656	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CTB89_RS03675	762806..762982	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	762970..763144	-	175	-	-	Antitoxin
CTB89_RS03685	763194..763448	+	255	WP_000611512.1	phage holin	-
CTB89_RS03690	763460..764215	+	756	WP_000861038.1	CHAP domain-containing protein	-
CTB89_RS03695	764406..764897	+	492	WP_000920037.1	staphylokinase	-
CTB89_RS03710	765547..765882	+	336	Protein_684	SH3 domain-containing protein	-
CTB89_RS03715	765977..766426	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CTB89_RS03720	767111..767461	+	351	WP_000702263.1	complement inhibitor SCIN-A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	745982..781120	35138

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T31333 WP_011447039.1 NZ_AP017891:762806-762982 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T31333 NZ_AP017891:762806-762982 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT31333 NZ_AP017891:c763144-762970 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin