Detailed information of TA system TA031313

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2613704..2614018
• Replicon: chromosome
• Accession: NZ_AP017623
• Organism: Enterococcus faecalis strain W11

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: EFW11_RS13050
• Protein ID: WP_096398070.1
• Coordinates: 2613704..2613826 (+)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2613759..2614018 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFW11_RS13030	2609337..2609969	-	633	WP_096398067.1	RloB family protein	-
EFW11_RS13035	2609978..2611273	-	1296	WP_002410675.1	AAA family ATPase	-
EFW11_RS13045	2611735..2613351	+	1617	WP_096398069.1	phosphatase PAP2/LCP family protein	-
EFW11_RS13050	2613704..2613826	+	123	WP_096398070.1	putative holin-like toxin	Toxin
-	2613759..2614018	-	260	NuclAT_5	-	Antitoxin
-	2613800..2614020	-	221	NuclAT_8	-	-
-	2613970..2614019	+	50	NuclAT_10	-	-
EFW11_RS13055	2614021..2617893	-	3873	WP_096398071.1	WxL domain-containing protein	-
EFW11_RS13060	2617874..2618242	-	369	WP_096398072.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4381.43 Da
• Isoelectric Point: 10.5782

>T31313 WP_096398070.1 NZ_AP017623:2613704-2613826 [Enterococcus faecalis]
MKGVGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 123 bp

>T31313 NZ_AP017623:2613704-2613826 [Enterococcus faecalis]
ATGAAAGGAGTAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGAT
TGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 260 bp

>AT31313 NZ_AP017623:c2614018-2613759 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATAAT
GGTAATGAAAAGAGAGATATGCGCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTAGCGATTTTTAGTGATTTA
TAAAAAATAACCGTGCTCGCTAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAA
AGCAATGGTAAACATACCAA

Structures

Antitoxin