Detailed information of TA system TA031306

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2537530..2537801
• Replicon: chromosome
• Accession: NZ_AP017623
• Organism: Enterococcus faecalis strain W11

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U4MH53
• Locus tag: EFW11_RS12675
• Protein ID: WP_073340330.1
• Coordinates: 2537649..2537801 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2537530..2537716 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFW11_RS12660	2532896..2533609	-	714	WP_002367455.1	trehalose operon repressor	-
EFW11_RS12665	2533871..2536615	+	2745	WP_096398051.1	glycoside hydrolase family 65 protein	-
EFW11_RS12670	2536630..2537280	+	651	WP_096398052.1	beta-phosphoglucomutase	-
-	2537349..2537488	+	140	NuclAT_9	-	-
-	2537530..2537716	+	187	NuclAT_6	-	Antitoxin
EFW11_RS12675	2537649..2537801	-	153	WP_073340330.1	putative holin-like toxin	Toxin
-	2537893..2538047	+	155	NuclAT_7	-	-
EFW11_RS12680	2538479..2538673	+	195	Protein_2357	CPBP family intramembrane metalloprotease	-
EFW11_RS12685	2538727..2539698	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
EFW11_RS12690	2539873..2540310	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
EFW11_RS12695	2540443..2540997	-	555	WP_002354869.1	septum formation protein Maf	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5665.96 Da
• Isoelectric Point: 11.0942

>T31306 WP_073340330.1 NZ_AP017623:c2537801-2537649 [Enterococcus faecalis]
VVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 153 bp

>T31306 NZ_AP017623:c2537801-2537649 [Enterococcus faecalis]
GTGGTGCGTATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 187 bp

>AT31306 NZ_AP017623:2537530-2537716 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTTT
TGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A4U4MH53

Antitoxin