Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 302253..302766 Replicon chromosome
Accession NZ_AP017579
Organism Rickettsia japonica strain OHH-1

Toxin (Protein)


Gene name yoeB Uniprot ID G4KME1
Locus tag BZI96_RS01690 Protein ID WP_014120591.1
Coordinates 302506..302766 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F3RGJ3
Locus tag BZI96_RS01685 Protein ID WP_014013992.1
Coordinates 302253..302495 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZI96_RS01665 297280..299049 - 1770 WP_024704469.1 ABC transporter ATP-binding protein/permease -
BZI96_RS01670 299230..299499 + 270 WP_014013989.1 DUF2671 domain-containing protein -
BZI96_RS01675 299654..301024 + 1371 WP_014120588.1 cytochrome ubiquinol oxidase subunit I -
BZI96_RS01680 301032..302051 + 1020 WP_014120589.1 cytochrome d ubiquinol oxidase subunit II -
BZI96_RS01685 302253..302495 + 243 WP_014013992.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BZI96_RS01690 302506..302766 + 261 WP_014120591.1 Txe/YoeB family addiction module toxin Toxin
BZI96_RS01695 302759..303607 + 849 WP_014120592.1 glycosyltransferase family 2 protein -
BZI96_RS01700 303684..304922 + 1239 WP_014120593.1 insulinase family protein -
BZI96_RS01705 305076..305786 + 711 WP_014120594.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
BZI96_RS01715 306015..307601 + 1587 WP_014120595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10254.07 Da        Isoelectric Point: 9.8788

>T31176 WP_014120591.1 NZ_AP017579:302506-302766 [Rickettsia japonica]
MYIIRYTTQAQKDAKKIVQAGLKNKVEVLLNIVSTDPWKIYPPYEKLVGDFSGCYSRRINIQHRLVCEVYKQEKVVKILR
MYTHYE

Download         Length: 261 bp

>T31176 NZ_AP017579:302506-302766 [Rickettsia japonica]
ATGTATATAATTCGTTATACTACACAAGCACAAAAAGATGCTAAGAAAATAGTGCAAGCCGGTTTAAAGAATAAAGTAGA
AGTTTTATTAAACATAGTTAGTACTGATCCTTGGAAAATTTACCCTCCATATGAAAAGCTCGTTGGTGACTTTAGCGGTT
GTTATTCAAGAAGAATTAATATTCAACATAGGTTGGTTTGTGAAGTTTACAAACAAGAAAAAGTTGTAAAAATTCTTAGA
ATGTATACGCATTATGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9405.83 Da        Isoelectric Point: 7.1617

>AT31176 WP_014013992.1 NZ_AP017579:302253-302495 [Rickettsia japonica]
MEIYNTSEARSKLYKLIDYVSDVHKPVYIKGKRNNVVIISEEDYRNMEETLYLLSIPNMHKSLIEGRAEPIAKCSDKLNW

Download         Length: 243 bp

>AT31176 NZ_AP017579:302253-302495 [Rickettsia japonica]
ATGGAAATATATAATACAAGCGAAGCAAGAAGTAAGCTTTATAAACTTATAGATTATGTTTCTGATGTACACAAACCTGT
TTATATTAAAGGTAAAAGAAATAATGTAGTTATAATTTCAGAAGAAGATTATCGTAATATGGAAGAAACTTTATATTTAT
TATCTATTCCAAATATGCATAAGTCTCTAATTGAAGGACGAGCAGAGCCTATAGCAAAGTGTAGCGATAAATTAAATTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3B7DC01

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3RGJ3

References